Genetic Basis of MIS-C in Children linked to COVID-19
Official title: Genetic Basis of SARS-CoV-2 Infection-Associated Multisystem Inflammatory Syndrome in Children (MIS-C)
Run by Istituto Giannina Gaslini · NCT07881068 · Data updated 2026-11-12
This study tests whether genetic factors contribute to MIS-C in children who have had COVID-19.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 2 Years to 65 Years |
| Sex | All |
| Enrollment | 150 (estimated) |
| Sponsor | Istituto Giannina Gaslini Academic / other |
| Locations | 3 sites (Bergamo and 2 other locations) |
| Status | Recruiting |
| Started | February 23, 2022 |
| Main results expected | December 31, 2026 |
| Study ends | December 31, 2026 |
| Registry record updated | October 19, 2026 |
| Trial ID | NCT07881068 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Children with clinical features characteristic of MIS-C and Kawasaki disease.
✕Probably not a fit
Children without MIS-C features or with other diseases may not benefit from this genetic-focused analysis.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This observational study investigates how genetics may influence MIS-C in pediatric patients identified by the IDEA network. It aims to describe genetic backgrounds, underlying mechanisms, and the range of clinical presentations, with goals to inform treatment strategies and follow-up planning. The study will help identify who is at higher risk for MIS-C after COVID-19 and may guide future personalized care.
Why it matters
Potential benefit: Understanding genetic risk factors could lead to better risk prediction and more tailored therapies for MIS-C.
How similar studies have gone: Previous research in pediatric inflammatory conditions suggests a genetic component can influence disease expression, supporting the plausibility of this approach.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Patients presenting with specific clinical features characteristic of MIS-C and Kawasaki disease. Exclusion Criteria: * Patients presenting with other diseases.
Where it's running
-
ASST Papa Giovanni XXIII
Bergamo, Italy Recruiting -
IRCCS Ospedale San Raffaele
Milan, Italy Recruiting -
IRCCS Materno-Infantile Burlo Garofolo
Trieste, Italy Recruiting
Study contacts
- Study coordinator: Angelo Ravelli
- Email: angeloravelli@gaslini.org
- Phone: +3901056363915
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.