Genetic analysis of familial and pediatric vasculitis
Official title: Identification of Susceptibility Loci and Genes for Systemic Vasculitis Risk, by Analyzing Whole Exome Sequencing of Familial and Pediatric Forms of Vasculitis (FAMILYVASC Study)
Run by French Vasculitis Study Group · NCT04006535 · Data updated 2026-11-12
This study is trying to find out if certain genes in families with children who have vasculitis can help us understand why some people get this condition.
Quick facts
| Study type | Observational |
|---|---|
| Sex | All |
| Enrollment | 100 (estimated) |
| Sponsor | French Vasculitis Study Group Academic / other |
| Locations | 1 site (Paris, Île-de-France Region) |
| Status | Recruiting |
| Started | June 1, 2019 |
| Main results expected | June 1, 2029 |
| Study ends | June 1, 2029 |
| Registry record updated | July 8, 2019 |
| Trial ID | NCT04006535 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates include children and adults diagnosed with vasculitis as per the Chapel Hill classification.
✕Probably not a fit
Patients who do not have vasculitis or are not related to someone with the condition may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
The FAMILYVASC study is a prospective observational study designed to identify genetic factors associated with systemic vasculitis in patients with familial or pediatric forms of the condition. It utilizes whole exome sequencing to analyze DNA obtained from saliva samples. The study aims to uncover susceptibility loci and genes that may contribute to the risk of developing vasculitis. Both affected individuals and healthy relatives will be included to provide a comprehensive genetic landscape.
Why it matters
Potential benefit: If successful, this study could lead to improved understanding and potential new treatments for patients with vasculitis.
How similar studies have gone: Other studies utilizing genetic analysis for similar conditions have shown promise, indicating potential for success in this approach.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion criteria for subjects with vasculitis * Children and adults * Patients with vasculitis, as defined in the Chapel Hill International Classification in its revised version of 2012 * Patient information and signed informed consent * Pregnant and breastfeeding women can be included in the study Inclusion criteria for healthy subjects * Children and adults * Do not have vasculitis, as defined in the Chapel Hill International Classification in its revised version of 2012, or relatives on the 1st; 2nd; 3rd or 4th degree of a patient with vasculitis * Patient information and signed informed consent * Pregnant and breastfeeding women can be included in the study Exclusion criteria: * Refusal of consent or inability to obtain consent * Dementia or unauthorized patient, for psychiatric or intellectual failure reasons, to receive information about the protocol and to give informed consent. * Uncooperative patient, or any pathology that could make the patient potentially non-compliant to the study procedures, and patients interned for regulatory or legal reasons.
Where it's running
-
Hôpital Cochin - Department of Internal Medicine
Paris, Île-de-France Region, France Recruiting
Study contacts
- Principal investigator: Benjamin Terrier, MD, PhD — French Vasculitis Study Group
- Study coordinator: Benjamin Terrier, MD, PhD
- Email: benjamin.terrier@aphp.fr
- Phone: +33 1 58 41 14 61
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.