Genetic analysis of familial and pediatric vasculitis
Identification of Susceptibility Loci and Genes for Systemic Vasculitis Risk, by Analyzing Whole Exome Sequencing of Familial and Pediatric Forms of Vasculitis (FAMILYVASC Study)
French Vasculitis Study Group · NCT04006535
This study is trying to find out if certain genes in families with children who have vasculitis can help us understand why some people get this condition.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 100 (estimated) |
| Sex | All |
| Sponsor | French Vasculitis Study Group (other) |
| Locations | 1 site (Paris, Île-de-France Region) |
| Trial ID | NCT04006535 on ClinicalTrials.gov |
What this trial studies
The FAMILYVASC study is a prospective observational study designed to identify genetic factors associated with systemic vasculitis in patients with familial or pediatric forms of the condition. It utilizes whole exome sequencing to analyze DNA obtained from saliva samples. The study aims to uncover susceptibility loci and genes that may contribute to the risk of developing vasculitis. Both affected individuals and healthy relatives will be included to provide a comprehensive genetic landscape.
Who should consider this trial
Good fit: Ideal candidates include children and adults diagnosed with vasculitis as per the Chapel Hill classification.
Not a fit: Patients who do not have vasculitis or are not related to someone with the condition may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved understanding and potential new treatments for patients with vasculitis.
How similar studies have performed: Other studies utilizing genetic analysis for similar conditions have shown promise, indicating potential for success in this approach.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion criteria for subjects with vasculitis * Children and adults * Patients with vasculitis, as defined in the Chapel Hill International Classification in its revised version of 2012 * Patient information and signed informed consent * Pregnant and breastfeeding women can be included in the study Inclusion criteria for healthy subjects * Children and adults * Do not have vasculitis, as defined in the Chapel Hill International Classification in its revised version of 2012, or relatives on the 1st; 2nd; 3rd or 4th degree of a patient with vasculitis * Patient information and signed informed consent * Pregnant and breastfeeding women can be included in the study Exclusion criteria: * Refusal of consent or inability to obtain consent * Dementia or unauthorized patient, for psychiatric or intellectual failure reasons, to receive information about the protocol and to give informed consent. * Uncooperative patient, or any pathology that could make the patient potentially non-compliant to the study procedures, and patients interned for regulatory or legal reasons.
Where this trial is running
Paris, Île-de-France Region
- Hôpital Cochin - Department of Internal Medicine — Paris, Île-de-France Region, France (RECRUITING)
Study contacts
- Principal investigator: Benjamin Terrier, MD, PhD — French Vasculitis Study Group
- Study coordinator: Benjamin Terrier, MD, PhD
- Email: benjamin.terrier@aphp.fr
- Phone: +33 1 58 41 14 61
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions: Vasculitis