Gene therapy for Retinitis Pigmentosa caused by CNGA1 mutations

A Prospective, Open-label, Phase 1b, Single-arm, Safety Study of an Intravitreal Application of a Recombinant Adeno-associated Virus Vector Expressing CNGA1 (AAV2.NN-CNGA1) in Patients With Retinitis Pigmentosa Due to CNGA1 Mutations

This study is testing a new gene therapy called VG901 to see if it is safe and can help people with Retinitis Pigmentosa caused by CNGA1 gene mutations.

Quick facts

• Phase: PHASE1
• Study type: Interventional
• Enrollment: 6 (estimated)
• Ages: 18 Years and up
• Sex: All
• Sponsor: VeonGen Therapeutics GmbH (industry)
• Locations: 1 site (Tübingen)
• Trial ID: NCT06291935 on ClinicalTrials.gov

What this trial studies

This phase 1 clinical trial aims to evaluate the safety and tolerability of a gene therapy called VG901 in patients diagnosed with Retinitis Pigmentosa due to mutations in the CNGA1 gene. Participants will receive a single intravitreal injection of VG901 into the most affected eye, with two cohorts receiving different doses. The study will monitor participants for one year to assess any side effects and early signs of efficacy on visual function.

Who should consider this trial

Good fit: Ideal candidates include adults aged 18 and older with a clinical diagnosis of Retinitis Pigmentosa and confirmed biallelic variants in the CNGA1 gene.

Not a fit: Patients with additional ocular conditions or mutations causing other inherited retinal diseases may not benefit from this study.

Why it matters

Potential benefit: If successful, this treatment could potentially improve visual function in patients with a rare genetic form of Retinitis Pigmentosa.

How similar studies have performed: While gene therapy for retinal diseases is an emerging field, this specific approach targeting CNGA1 mutations is novel and has not been extensively tested in prior studies.

Eligibility criteria

Inclusion Criteria:

To be eligible for study entry, subjects must satisfy all the following criteria:

1. Able to understand and willing to consent to study participation by a written informed consent
2. Male or female ≥ 18 years of age
3. Clinical diagnosis of RP
4. Confirmed pathogenic, biallelic variants in the CNGA1 gene
5. Ellipsoid zone (EZ) length of the fovea of ≥ 3000 μm in the study eye

Exclusion Criteria:

Subjects will be excluded from the study if one or more of the following statements are applicable to either eye:

1. Additional interfering ocular conditions which would impact study results (e.g., ocular opacity and advanced cataract, uveitis, amblyopia)
2. History or presence of glaucoma
3. Ocular surgery, intravitreal or subretinal implantation of a medical device (within 6 months of screening)
4. Mutations known to cause inherited retinal disease other than biallelic variants in the CNGA1 gene
5. History of ocular infection with herpes simplex virus
6. History of ocular malignancies
7. History of disorders of the internal retina (e.g., retinal detachment)
8. Patients with uncontrolled diabetes (HbA1c \> 7%)
9. Any other retinopathy due to other diseases - including, but not limited to arterial hypertension, previous vascular retinal occlusion, trauma or acquired inflammatory diseases, contraindication to pharmacological mydriasis (e.g., history of angle block glaucoma), diabetes (diabetic retinopathy including macular oedema)
10. Absence of visual function on the contralateral eye
11. Any damage to the optic nerve
12. Individuals performing any other therapy for RP within 3 months before the study, such as - but not limited to - transcorneal electrostimulation
13. Systemic conditions (e.g., autoimmune disorders) which may affect study participation or outcome measures
14. History of immunodeficiency or other medical conditions which may increase the risk of VG901 administration
15. Systemic illness (e.g., hepatitis or human immunodeficiency virus \[HIV\] infection) or medically relevant abnormal laboratory values (3 x upper limit of normal \[ULN\]) in blood analysis including renal and hepatic function
16. Current, or recent, participation in other study/ or administration of investigational biologic agent within 3 months of Screening; Use of any investigational agent, or systemic corticosteroids, or other immunosuppressive drug(s) within 3 months before Screening
17. History of allergy or sensitivity to any compound used in the study
18. Contraindications to systemic immunosuppression
19. Subjects with increased risk of bleeding (i.e., use of anticoagulants or anti-platelet agents within 7 days before VG901 administration and subjects with international normalized ratio \> 2 or Quick \< 50% or partial thromboplastin time \> 50 seconds, thrombocytopenia, as well as any other known coagulopathy)
20. Subject/partner of childbearing potential unwilling to use adequate contraception for the period between Screening and 30 days after treatment, defined as the period from Screening until 30 days after treatment (defined as administration of therapeutic to the eye)
21. For females of childbearing potential, a positive pregnancy test at Screening or Baseline
22. Females who are breastfeeding
23. Previous receipt of any AAV gene therapy product
24. Any condition which leads the investigator to believe that subject cannot comply with the protocol requirements or that may place the subject at an unacceptable risk from participating

Where this trial is running

Tübingen

• Center for Ophthalmology, University of Tuebingen — Tübingen, Germany (RECRUITING)

Study contacts

• Principal investigator: Katarina Stingl — Center for Ophthalmology, University of Tuebingen
• Study coordinator: Andrea Rindtorff

Conditions: Retinitis Pigmentosa, CNGA1 mutation, AAV2, Gene Therapy, Eye disease