Gene profiling of cumulus cells after CAPA‑IVM
Official title: Transcriptomic Profiling of Cumulus Cells From CAPA-IVM Cycles in Women With PCOS: A Prospective Pilot Study
Run by Mỹ Đức Hospital · NCT07197255 · Data updated 2026-11-12
This pilot will test whether gene patterns in cumulus cells collected after CAPA‑IVM can help predict egg and embryo quality for women with PCOS undergoing CAPA‑IVM.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years to 38 Years |
| Sex | Women only |
| Enrollment | 10 (estimated) |
| Sponsor | Mỹ Đức Hospital Academic / other |
| Locations | 1 site (Ho Chi Minh City) |
| Status | Recruiting |
| Started | October 16, 2025 |
| Main results expected | January 30, 2026 |
| Study ends | March 30, 2026 |
| Registry record updated | November 21, 2025 |
| Trial ID | NCT07197255 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Women aged 18–38 with PCOS by Rotterdam criteria, BMI ≤32 kg/m2, AMH ≥4 ng/mL and AFC ≥24 who are scheduled for CAPA‑IVM are ideal candidates.
✕Probably not a fit
Women without PCOS, with low ovarian reserve (AMH <4 ng/mL or AFC <24), those using surgically retrieved sperm, or those not undergoing CAPA‑IVM are unlikely to benefit from participation.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This prospective observational cohort at My Duc Hospital will enroll women with PCOS undergoing CAPA‑IVM and collect cumulus cells from individual cumulus–oocyte complexes following a single‑culture CAPA‑IVM protocol. RNA sequencing will be performed using low‑input methods and analyzed with differential expression tools (DESeq2) and pathway analyses such as Gene Ontology and Ingenuity. The molecular profiles of cumulus cells will be correlated with embryology outcomes including fertilization, day‑3 cleavage, and blastocyst formation. The study aims to identify transcriptomic signatures that could serve as non‑invasive biomarkers of oocyte competence to inform embryo selection.
Why it matters
Potential benefit: If successful, this approach could provide a non‑invasive biomarker from cumulus cells to help select the best oocytes and embryos and potentially improve IVF success for women with PCOS.
How similar studies have gone: CAPA‑IVM has been linked to improved oocyte maturation and live births, and prior studies have shown correlations between cumulus cell gene expression and oocyte quality, but reliable transcriptomic predictors of embryo outcomes are still preliminary.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Women 18-38 years * BMI =\< 32kg/m2 * Diagnosed with polycystic ovary syndrome (PCOS) according to the Rotterdam 2003 criteria, meet at least 2 of the following 3 features: (1) Oligo-ovulation or anovulation. (2) Clinical and/or biochemical signs of hyperandrogenism (3) Polycystic ovarian morphology on ultrasound. * Indicated for CAPA-IVM treatment. * Serum AMH ≥ 4 ng/mL (28.57 pmol/L). * Antral follicle count (AFC) ≥ 24 follicles in both ovaries at the time of CAPA-IVM indication. * Signed informed consent to participate in the study. Exclusion Criteria: * Retrieved sperm from surgical procedures * Previous IVF cycle with total immature oocytes
Where it's running
-
My Duc Hospital
Ho Chi Minh City, Vietnam Recruiting
Study contacts
- Principal investigator: Lan N Vương, PhD, MD — University of Medicine and Pharmacy at Ho Chi Minh City
- Study coordinator: Huy H Pham, MSc.
- Email: huy.ph@myduchospital.vn
- Phone: +84966145510
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
-
Ovarian drilling via vNOTES laparoscopy for PCOS patients
This study tests whether drilling the ovaries using vNOTES laparoscopy can help women with PCOS who did not respond to first-line medicines.
-
PMOS and Sleep Apnea: A Pilot Look at Mitochondrial Function
In women with PMOS, this pilot study tests whether sleep apnea treatment with CPAP improves mitochondrial function in leg muscle tissue.
-
Lean Beef as Part of a Healthy Meal Plan for Adolescent Girls with PCOS/PMOS
This pilot study tests a lean beef–based meal plan to see if it improves blood sugar control and diet quality in adolescent girls with PCOS/PMOS.
-
Inositol and Metformin with Mediterranean or Low-Carb Diets in Women with PCOS
This trial tests whether adding inositol, metformin, or folic acid to either a Mediterranean or a low-carbohydrate diet helps women with PCOS and insulin resistance lose weight and improve metabolic markers.
-
Fecal microbiota transplantation for overweight women with PMOS undergoing embryo transfer
We are testing if oral FMT capsules are safe and can improve pregnancy outcomes for overweight/obese women with PMOS undergoing frozen embryo transfer.
-
Glp-1/FGF21 dual agonist for PCOS treatment
This study tests a GLP-1/FGF21 dual agonist to see if it helps women with PCOS by improving weight, hormones, and menstrual health.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.