Fusion imaging to guide clot-removal procedures for acute ischemic stroke
Official title: Fusion Imaging in Endovascular Thrombectomy for Acute Ischemic Stroke
Run by Region Skane · NCT06975696 · Data updated 2026-11-12
This trial will test whether using CT-to-live angiography fusion imaging during endovascular thrombectomy helps doctors open blocked large brain arteries faster and more often in adults with acute ischemic stroke.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 300 (estimated) |
| Sponsor | Region Skane Academic / other |
| Drugs / interventions | radiation |
| Locations | 4 sites (Helsinki and 3 other locations) |
| Status | Recruiting |
| Started | March 2, 2026 |
| Main results expected | May 31, 2027 |
| Study ends | May 31, 2027 |
| Registry record updated | March 4, 2026 |
| Trial ID | NCT06975696 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults (age ≥18) with acute ischemic stroke who are eligible for endovascular thrombectomy and have a preoperative CT angiogram available are ideal candidates.
✕Probably not a fit
Patients without a preoperative CTA or those treated at centers that cannot perform 2D/3D fusion imaging are unlikely to receive benefit from this approach.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This is a multinational, multicenter, prospective randomized trial comparing standard endovascular thrombectomy (EVT) with and without preprocedural CT-to-angiography 2D/3D fusion imaging. Participating operators will prepare 3D reconstructions from preoperative CTA and fuse them with live fluoroscopy or digital subtraction angiography during the procedure after standardized training. Approximately 300 adult patients eligible for EVT will be randomized to EVT plus Fusion or EVT alone, with primary outcomes including successful recanalization, first-pass effect, and procedure time. The fusion workflow is designed to be prepared before patient arrival and applied intra-procedurally in under a minute to avoid meaningful delays.
Why it matters
Potential benefit: If successful, fusion imaging could increase first-pass and overall recanalization rates and shorten procedure times, potentially improving functional outcomes after large-vessel ischemic stroke.
How similar studies have gone: A prior observational study reported increases in recanalization from 82% to 100% and first-pass recanalization from 49% to 72% with fusion imaging, but randomized evidence is limited.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: 1. Age ≥18 years. 2. Eligible for an EVT procedure Exclusion Criteria: 1. Previous inclusion in this study 2. No access to a preoperative CTA
Where it's running
-
Skane University Hospital Lund
Lund, Sweden Recruiting -
Helsinki University Central Hospital
Helsinki, Finland Not yet recruiting -
Turku University Hospital
Turku, Finland Not yet recruiting -
Örebro University Hospital
Örebro, Sweden Not yet recruiting
Study contacts
- Principal investigator: Johan Wasselius, MD, PhD — Skåne University Hospital and Lund University
- Study coordinator: Johan Wasselius, MD, PhD
- Email: johan.wasselius@gmail.com
- Phone: +46-46173082
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.