Frequency of GBA and PSAP Gene Variants in Patients with MM or MGUS

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study will evaluate the presence and number of mutated alleles in the GBA and PSAP genes among patients with multiple myeloma or MGUS. Researchers will analyze genetic data to explore potential links between these rare gene alterations and chronic plasma cell disorders. The aim is to better understand how metabolic network changes might relate to disease mechanisms and identify potential therapeutic targets. Participants are adults who meet the disease criteria and provide informed consent.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Major patients with multiple myeloma (MM) (defined by clonal proliferation of tumour plasma cells (\>10%), presence of a monoclonal peak in serum or urine (excluding non-secretory myeloma) and organ involvement secondary to bone marrow invasion) or with MGUS (defined as bone marrow plasmacytosis of less than 10%, associated with a monoclonal protein of less than 30g/L and no clinical involvement).
* Membership of a social security scheme
* Adult having read and understood the information letter and signed the consent form

Exclusion Criteria:

* Person deprived of liberty by an administrative or judicial decision or person placed under court protection / sub-guardianship or guardianship

Where it's running

• University Rouen Hospital
  Rouen, France Recruiting
• Centre Henri Becquerel
  Rouen, France Not yet recruiting

Study contacts

• Study coordinator: Abdellah AB TEBANI, Pr
• Email: Abdellah.Tebani@chu-rouen.fr
• Phone: 02 32 88 81 24

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.