Freezing testicular tissue to help preserve fertility in young boys with cancer

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study aims to cryopreserve testicular tissue from prepubertal boys who are about to undergo cancer treatment that poses a high risk of infertility. With informed consent from guardians, testis tissue biopsies will be collected and frozen for future use in restoring fertility. The study also includes laboratory research to understand germ cell development and optimize freezing methods. Patients will be followed up to assess the long-term effects of the procedure on their endocrine function.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Pre- and peripubertal boys
* Due to receive cancer treatment that is predicted to have a high risk (\>80%) of infertility
* Consent to removal of testicular tissue for storage and research
* Unable to produce a semen sample by masturbation

Exclusion Criteria:

* Participation in study would delay treatment
* Too unwell to undergo the procedure
* Pre-existing testicular pathology/previous testicular surgery (eg orchidopexy)
* Able to produce a semen sample for cryopreservation

Where it's running

• University of Edinburgh
  Edinburgh, Lothian, United Kingdom Recruiting

Study contacts

• Principal investigator: Rod T Mitchell, MBChB — University of Edinburgh

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Preserving fertility in boys undergoing cancer treatment

  This study is testing a way to help young boys with cancer keep their ability to have children in the future by freezing their testicular tissue before treatment.

  Recruiting at 3 sites University Hospital, Geneva · Basel and 2 other locations · NCT03180918

• Community-led, family-centered communication for Hispanic childhood cancer survivors

  This study tests a family-focused communication approach to help young Hispanic adult survivors, their families, and clinicians talk more effectively about survivorship care.

  Recruiting Stanford University · Palo Alto, California · NCT07606443

• Blood biomarkers for treatment-related brain injury in children with brain tumors

  This project will test whether blood plasma biomarkers can show treatment-related brain injury in children with primary brain tumors by comparing those who receive radiotherapy, those who do not, and healthy children of the same age and sex.

  Recruiting Uppsala University · Uppsala · NCT07381959

• At-home light therapy for chemo-related nerve pain in childhood cancer survivors

  This study tests whether a six-week at-home light therapy program can help childhood cancer survivors who have chemotherapy-induced peripheral neuropathy.

  Recruiting at 2 sites Yale University · New Haven, Connecticut and 1 other locations · NCT07019259

• Developing an AI tool to predict embryo quality from time‑lapse incubator images

  This project will test an AI program that analyzes time‑lapse embryo images to help embryologists identify higher‑quality embryos for people having IVF or egg‑freezing.

  Recruiting Fairtility · Stamford, Connecticut · NCT07017972

• Menopur and Rekovelle combination for personalized ovarian stimulation

  This test will see if starting Rekovelle and Menopur doses set by a woman's age and weight work as well as doses set by AMH and weight for women aged 18–40 having IVF.

  Recruiting at 2 sites Phase 2 Clinique Ovo · Ottawa, Ontario and 1 other locations · NCT06997900

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.