Freezing ovarian tissue to help women at risk of losing fertility

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study focuses on the cryopreservation of ovarian tissue to preserve fertility in women who are at risk of premature ovarian failure due to cancer treatments or surgical interventions. Participants will undergo a thorough preoperative assessment, including imaging and blood tests, to evaluate ovarian function and reserve. Depending on the findings, one or both ovaries may be surgically removed for cryopreservation. The goal is to develop techniques that allow for the maturation of immature eggs, enabling women to conceive a genetically related child in the future.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Females 0-45 years of age who are premenopausal
* Treatment plan that will likely result in premature menopause or premature ovarian failure
* This includes patients receiving:
* Cancer treatment with abdominal pelvic irradiation and/or high dose chemotherapy
* Surgery that requires removal of ovaries for medical condition or disease, e.g. Prophylactic oophorectomy in BRCA patients
* Patient is unable or unwilling to pursue fertility preservation by freezing oocytes or embryos.
* Previous treatment for cancer is acceptable if patient still has ovarian function
* Patient is medically stable enough to undergo surgery (cleared for anesthesia)

Exclusion Criteria:

* Patients not meeting the above criteria
* Patients who have not received medical clearance from their physicians to undergo surgery
* Patients already experiencing menopause.

Where it's running

• Ronald O. Perelman and Claudia Cohen Center for Reproductive Medicine
  New York, New York, United States Recruiting

Study contacts

• Principal investigator: Glenn Schattman, MD — Weill Medical College of Cornell University
• Study coordinator: Rodriq E. Stubbs, NP
• Email: res2011@med.cornell.edu
• Phone: 646-962-3276

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Follicular Flushing During Abdominal Egg Retrieval in Women with Low Egg Reserve

  This study tests whether rinsing the egg sacs during abdominal egg collection yields more eggs and more mature eggs for freezing in women with low ovarian reserve.

  Recruiting at 2 sites Centrum Clinic IVF Center · Ankara, Ankara and 1 other locations · NCT07877025

• GnRH agonist versus dual hCG/GnRH trigger for ovulation induction in fertility preservation

  We will test whether using a GnRH agonist alone or a dual trigger (GnRH agonist plus hCG) gives better egg retrieval numbers and safety for people with cancer doing egg freezing before gonadotoxic treatment.

  Recruiting IRCCS Azienda Ospedaliero-Universitaria di Bologna · Bologna, Bologna · NCT07546136

• Combining ovarian tissue freezing with egg (oocyte) freezing versus egg freezing alone

  This research will test whether combining ovarian tissue freezing with egg freezing helps adult women with cancer preserve more fertility than egg freezing alone.

  Recruiting IRCCS Azienda Ospedaliero-Universitaria di Bologna · Bologna, Bologna · NCT07546123

• Long-term follow-up of fertility preservation in women after cancer remission

  This project will see how fertility preservation options work long-term for women in remission from cancer or hematological disease, including how often preserved material is used and the psychological effects.

  Recruiting Centre Hospitalier Universitaire, Amiens · Amiens · NCT07312058

• When to start hormones after stopping combined birth control for planned egg freezing

  This trial tests whether taking a two-month break from combined hormonal birth control versus starting ovarian stimulation immediately affects outcomes for ovary-bearing people aged 18–40 who are planning to freeze their eggs.

  Recruiting at 2 sites Shady Grove Fertility Reproductive Science Center · Orange, Connecticut and 2 other locations · NCT07225660

• Fertility-preserving hysteroscopic treatment outcomes for endometrial cancer and atypical hyperplasia

  This project tests whether removing lesions by hysteroscopy combined with hormonal therapy helps women with endometrial cancer or atypical hyperplasia preserve fertility and achieve good pregnancy and cancer-control outcomes.

  Recruiting Fondazione Policlinico Universitario Agostino Gemelli IRCCS · Roma · NCT07077876

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.