fMRI imaging of social cognition in adolescent girls with BPD, ADHD, and healthy peers
Official title: Feasibility Study Using Functional Magnetic Resonance Imaging (fMRI) on Bordeline Personality Disorders in Adolescents
Run by Etablissement Public de la Sante Mentale de la Somme · NCT07540429 · Data updated 2026-11-12
This project tests whether fMRI scans can detect differences in brain activity during social-cognitive and cognitive-control tasks in adolescent girls with borderline personality disorder compared with girls with ADHD and healthy peers.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 12 Years to 17 Years |
| Sex | Women only |
| Enrollment | 21 (estimated) |
| Sponsor | Etablissement Public de la Sante Mentale de la Somme Research network |
| Locations | 1 site (Dury) |
| Status | Recruiting |
| Started | June 8, 2024 |
| Main results expected | June 8, 2027 |
| Study ends | December 31, 2027 |
| Registry record updated | April 20, 2026 |
| Trial ID | NCT07540429 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Female adolescents who are euthymic at the time of testing and meet DIB-R criteria for BPD, meet KSADS-PL criteria for ADHD, or have no psychiatric disorder, and who have no MRI contraindications.
✕Probably not a fit
Males, participants who are not euthymic, and those with significant head trauma, chronic neurologic disease, pregnancy, claustrophobia, or any MRI contraindication are unlikely to benefit from participation.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
Female adolescents are enrolled into three groups—those meeting DIB-R criteria for BPD, those meeting KSADS-PL criteria for ADHD, and healthy controls screened with the CBCL and Ab-DIB—and all are euthymic at the time of testing. Participants complete diagnostic interviews and safety screening before undergoing task-based fMRI to probe social cognition and cognitive control. The investigators compare activation patterns and feasibility metrics across groups to increase knowledge of neural correlates associated with BPD in adolescence. The work is conducted at EPSM de la Somme in collaboration with CHU Amiens and is primarily exploratory and feasibility-focused.
Why it matters
Potential benefit: If successful, the findings could help identify brain activity patterns linked to adolescent BPD, which may inform earlier recognition and more targeted interventions.
How similar studies have gone: Previous small Franco-Canadian work has shown that fMRI in Quebec adolescents with BPD is feasible, but replicated biomarkers and definitive findings remain limited.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Female adolescents meeting DIB-R criteria for BPD group * Female adolescents meeting kSADS-PL for ADHD group * Female adolescents without any psychologic disorders Exclusion Criteria: * Any medical history with head trauma, chronic neurologic disease, any contraindications for fRMI, claustrophobia or pregnancy.
Where it's running
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EPSM de la Somme
Dury, France Recruiting
Study contacts
- Principal investigator: Jean Marc GUILE, Professor — EPSM de la Somme
- Study coordinator: MICHAEL MONET, PhD
- Email: unite.2.recherche@epsm-somme.fr
- Phone: 0322534612
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.