Fish oil supplementation to improve sperm quality in men
A Randomised, Double Blinded Study to Determine the Effect of Supplementation With Fish Oil (EPAX EVOLVE 05) on Sperm Quality in Healthy Men.
This study is testing whether taking fish oil supplements can improve sperm quality in men who have low semen quality.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 80 (estimated) |
| Ages | 18 Years to 55 Years |
| Sex | Male |
| Sponsor | Epax Norway AS Industry-sponsored |
| Locations | 1 site (Oslo) |
| Trial ID | NCT06950203 on ClinicalTrials.gov |
What this trial studies
This study investigates the effects of fish oil supplementation on sperm quality in men with poor semen parameters. Participants will be randomly assigned to receive either fish oil capsules or a placebo for a duration of three months. Sperm samples will be collected at the beginning and end of the study to assess changes in quality. The study employs a double-blind design to ensure unbiased results, with both participants and assessors unaware of the treatment assignments.
Who should consider this trial
Good fit: Ideal candidates for this study are men aged 18-55 with documented poor sperm quality.
Not a fit: Patients with known allergies to fish products or specific medical conditions affecting sperm quality may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could provide a new dietary intervention to enhance male fertility.
How similar studies have performed: Previous studies have shown promising results with omega-3 fatty acids in improving sperm quality, suggesting this approach may be effective.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: 1. Men aged 18-55 2. Referred for or claiming a semen analysis. 3. Willing to have at least 2 days abstinence of sexual activity prior to a sperm sample being taken. 4. Reduced semen quality defined as: • Progressive motility: \<30% 5. Willing to refrain from omega-3/cod liver oil supplementation during the study. Use of other supplements is allowed. \- Exclusion Criteria: 1. Known allergy to fish products 2. Historically, known, or suspected bacterial infection in reproductive organs 3. Varicocele suspected from physical examination 4. Azoospermia 5. Diagnosis of diabetes (type 2) 6. Diagnosis of Crohn´s Disease 7. Inferior semen quality due to medical reasons, such as cryptorchidism (via questionnaire/medical records) -
Where this trial is running
Oslo
- Medicus Group AS — Oslo, Norway (Recruiting)
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.