First-Trimester Screening for Open Neural Tube Defects with Fetal Biometrics and Maternal Markers

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This retrospective study analyzes data from first-trimester ultrasounds and maternal serum markers to see how well fetal measurements and biochemical markers predict open neural tube defects. The researchers examine each parameter alone and in combination to establish practical screening thresholds for routine care. Data come from Strasbourg University Hospitals between 2011 and 2023, focusing on singleton pregnancies with no data gaps. The goal is to identify a reliable, early screening approach that could be used in everyday obstetric practice. Findings may inform future prospective validation and potential screening guidelines.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Adult pregnant woman (≥18 years)
* First-trimester ultrasound performed at Strasbourg University Hospitals between 01/01/2011 and 31/12/2023
* No written opposition to reuse of medical data for research purposes

Exclusion Criteria:

* Written opposition to reuse of medical data for research purposes
* Multiple pregnancy
* Presence of fetal growth abnormality, morphological or genetic anomaly during pregnancy
* Crown-rump length \<45 mm or \>84 mm at screening ultrasound
* Missing data
* Fetus with closed dysraphism

Where it's running

• Service de Gynécologie et Obstétrique - CHU de Strasbourg - France
  Strasbourg, France Recruiting

Study contacts

• Study coordinator: Chris Minella, MD
• Email: chris.minella@chru-strasbourg.fr
• Phone: 33 3 88 12 74 95

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.