Finding the best electrical stimulation settings to reduce seizures in epilepsy
Optimal Stimulation Parameters for Spike-ripple Disruption in Patients Undergoing Invasive Monitoring
This study is testing different electrical stimulation settings to see if they can better reduce seizures in people with hard-to-treat epilepsy.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 30 (estimated) |
| Sex | All |
| Sponsor | Massachusetts General Hospital Academic / other |
| Locations | 1 site (Boston, Massachusetts) |
| Trial ID | NCT06141668 on ClinicalTrials.gov |
What this trial studies
This study aims to optimize electrical stimulation parameters to effectively disrupt epileptiform activity in patients with refractory epilepsy. By comparing stimulation settings derived from rodent models to those currently used in clinical practice, the research seeks to establish a more effective approach to neuromodulation. Participants will be individuals undergoing intracranial EEG investigations at Massachusetts General Hospital as part of their presurgical evaluation for epilepsy. The study employs an open-loop stimulation method to assess the impact of different parameters on seizure activity.
Who should consider this trial
Good fit: Ideal candidates for this study are patients undergoing intracranial EEG investigations for presurgical evaluation of refractory epilepsy.
Not a fit: Patients with a baseline spike ripple rate of less than 0.5 per minute may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to more effective treatments for patients with refractory epilepsy, potentially reducing seizure frequency and improving quality of life.
How similar studies have performed: While there have been studies on electrical stimulation for epilepsy, this specific approach of optimizing parameters based on rodent models is relatively novel.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: - Undergoing intracranial EEG investigation at Massachusetts General Hospital during presurgical epilepsy evaluation Exclusion Criteria: - Baseline spike ripple rate \< 0.5/min.
Where this trial is running
Boston, Massachusetts
- Massachusetts General Hospital — Boston, Massachusetts, United States (Recruiting)
Study contacts
- Principal investigator: Catherine Chu, MD — Massachusetts General Hospital
- Study coordinator: Catherine Chu, MD
- Email: cjchu@mgh.harvard.edu
- Phone: 617726-6540
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.