Finding genetic variants in patients with heart failure undergoing breast cancer treatment

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This research focuses on using whole exome sequencing to identify genetic variants in germline DNA samples from patients who have congestive heart failure while receiving treatment for breast cancer. The study aims to analyze previously collected DNA samples to uncover rare variants that may influence the risk of developing heart failure in these patients. By understanding the genetic changes associated with heart failure, the research could lead to better biomarkers and treatment strategies for affected individuals.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* European American patients with DNA available
* European American patients who developed CHF and patients who did not develop CHF following a full course of treatment with an anthracycline and bevacizumab
* African American cases (based on a drop in left ventricular ejection fraction \[LVEF\] \< 50 or a drop from baseline \> 20 points) and African American controls

Where it's running

• Eastern Cooperative Oncology Group
  Boston, Massachusetts, United States Recruiting

Study contacts

• Principal investigator: Bryan P Schneider — Eastern Cooperative Oncology Group

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.