Finding and treating long-term effects of repeated mild brain injuries in older adults

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

The project combines NeuroTracker-based perceptual-cognitive testing and training with advanced MRI scans and blood-based biomarkers to detect lingering effects of past mild traumatic brain injuries in older adults. Researchers will enroll men and women aged 60+ with and without a history of concussion (most recent concussion at least one year prior) and compare cognitive, imaging, and biomarker profiles. Participants will undergo baseline cognitive testing, MRI, and blood draws; those with concussion history will receive NeuroTracker training with pre- and post-intervention measurements. The goal is to determine whether this multimodal approach improves sensitivity for detecting long-term concussion effects and whether NeuroTracker can produce measurable cognitive benefits.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* It will be based on age (60+ years) and history of concussion (with the most recent concussion occurring at least one year prior to the study). Consistent with the literature, the history of concussion will be determined by interviewing participants about their experience with each experience of concussion (e.g. how was the injury sustained (sports injury, vehicle accident, etc.), how long has it been since the injury, did they experience a loss of consciousness during the event, how was their concussion diagnosed, what were their symptoms and when did the symptoms resolve).

The interview will also gather information on age, sex, gender, education, occupation, and medical history (e.g. mood, medications). These variables will be coded and included in analyses, as appropriate. For example, years of education and years since the most recent concussion can be used as covariates.

Exclusion Criteria:

* Include the presence of a diagnosed neurological disorder (e.g. Mild Cognitive Impairment, Alzheimer's disease, Parkinson's disease), history of severe psychiatric disorder (e.g. schizophrenia), or any condition or medication that could affect cognition (e.g. psychotropic, anticholinergic drugs). Exclusion criteria also screen out the presence of any diagnosed visual impairment that could impede NeuroTracker training (i.e. severe colour blindness, monocular vision, blindness), and contraindications for MRI (e.g. metal implants).

Where it's running

• Christie Lab
  Victoria, British Columbia, Canada Recruiting
• Jodie Gawryluk
  Victoria, British Columbia, Canada Recruiting
• Faubert Lab
  Montreal, Quebec, Canada Recruiting

Study contacts

• Principal investigator: Jocelyn Faubert Principal Investigator, PhD — Université de Montréal
• Study coordinator: Eduardo Lugo Project Manager, PhD
• Email: eduardo.lugo.arce@umontreal.ca
• Phone: 1-514-441-9197

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Assessing mental health risks in adolescents with mild traumatic brain injury

  This study is trying to create a tool that helps doctors predict which teens aged 11 to 17 who have had a mild brain injury might develop new or worsening mental health issues.

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• Program to improve health after concussion in youth

  This study is testing a new online program that helps teenagers aged 11-18 who have ongoing symptoms after a concussion feel better and improve their quality of life.

  Recruiting Seattle Children's Hospital · Dallas, Texas · NCT06036147

• Comparing two therapies for insomnia in veterans with traumatic brain injury

  This study is testing whether online therapy for insomnia or mindfulness techniques can help veterans with brain injuries sleep better and feel less depressed.

  Recruiting at 5 sites Johns Hopkins University · Eglin Air Force Base, Florida and 4 other locations · NCT05663034

• Impact of dietary and nutritional intervention on post-concussive symptoms

  This study is testing whether changes in diet and nutrition can help people with ongoing concussion symptoms feel better compared to those getting just supplements or physiotherapy.

  Recruiting Universite de Moncton · Moncton, New Brunswick · NCT05589064

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.