Fat grafting plus latissimus dorsi muscle flap for delayed breast reconstruction
Official title: The Outcomes of Fat Grafting Combined With Latissimus Dorsi Muscle Flap for Delayed Breast Reconstruction After Mastectomy
Run by Sohag University · NCT07331753 · Data updated 2026-11-12
This will try adding fat grafting to a latissimus dorsi muscle flap to rebuild breasts in women who previously had a mastectomy.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years and up |
| Sex | Women only |
| Enrollment | 20 (estimated) |
| Sponsor | Sohag University Academic / other |
| Locations | 1 site (Sohag, Sohag Governorate) |
| Status | Recruiting |
| Started | November 1, 2025 |
| Main results expected | November 1, 2026 |
| Study ends | November 1, 2027 |
| Registry record updated | January 12, 2026 |
| Trial ID | NCT07331753 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Women indicated for skin-sparing mastectomy who seek delayed autologous breast reconstruction and do not have distant metastatic disease are the intended candidates.
✕Probably not a fit
Women with stage IV (metastatic) breast cancer or those who are medically unfit for surgery are unlikely to receive benefit from this procedure.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
The protocol combines a latissimus dorsi muscle flap with autologous fat grafting to perform delayed breast reconstruction after mastectomy. Eligible women undergo flap reconstruction with simultaneous fat harvest and transfer at Sohag University Hospital. Surgical outcomes such as contour, volume retention, complications, and donor-site morbidity will be recorded during follow-up. The goal is to determine whether the combined technique improves aesthetic results and reduces the need for additional procedures.
Why it matters
Potential benefit: If successful, the approach could provide a more natural breast shape and reduce the need for additional touch-up surgeries.
How similar studies have gone: Similar approaches combining latissimus dorsi flaps with autologous fat grafting have been reported to improve contour and patient satisfaction, though randomized trials are limited.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * female patient indicated for skin sparying mastectomy Exclusion Criteria: * female patients with stage 4 breast cancer
Where it's running
-
Sohag university hospital
Sohag, Sohag Governorate, Egypt Recruiting
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
-
EndoBreast: Feasibility and outcomes of nipple-sparing endoscopic mastectomy with immediate reconstruction
This observational study tests whether endoscopic nipple-sparing mastectomy with immediate reconstruction is feasible and acceptable for women at risk or with breast cancer.
-
Access My Breast Cancer Care App
A breast cancer care app is being tested to see if it helps patients navigate care, feel more satisfied, and reduce in-person visits.
-
Autologous Fat Grafting vs DIEP flap for reconstructed breast after radiation
This study tests whether autologous fat transfer can provide similar satisfaction and safety to the DIEP flap procedure for women needing breast reconstruction after mastectomy and radiation.
-
Prehabilitation with physiotherapy and mechanical stimulation before LD flap breast reconstruction
This study tests whether prehabilitation with physiotherapy and mechanostimulation improves shoulder pain and mobility for women undergoing breast reconstruction with a latissimus dorsi flap.
-
Hypofractionated radiotherapy after prosthetic breast reconstruction
This study tests whether a shorter, higher-dose radiotherapy course (HFRT) works as safely and effectively as the standard longer course (CFRT) for patients who had a mastectomy with implant reconstruction.
-
Implant-based breast reconstruction after bariatric (weight-loss) surgery
This registry-based project will use national data to see how common breast implants are and whether women who've had bariatric weight-loss surgery have different complication rates after implant-based breast augmentation or reconstruction.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.