FAPI Imaging to gauge revascularization outcomes in ischemic heart failure

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This prospective cohort study follows adults with ischemic heart failure who have undergone revascularization (PCI or CABG) to see if fibroblast activation protein inhibitor (FAPI) imaging with 18F can identify patients most likely to benefit. The study builds on existing imaging methods by focusing on activated fibroblasts as a marker of myocardial injury and recovery potential. Outcomes will relate imaging findings to post-procedure prognosis and remodeling, in the context of ongoing debates about viability imaging. The trial aims to clarify whether non-invasive FAPI imaging can improve patient selection for revascularization and guide future decision-making in IHF care.

Why it matters

Who can join: the full rules

Inclusion Criteria:

① Age ≥ 18 years; ② Meet the above-mentioned IHF diagnostic criteria; ③ Coronary angiography shows suitability for revascularization (PCI or CABG); ④ NYHA cardiac function classification is II-IV; ⑤ Sign the informed consent form.

Exclusion Criteria:

① Heart failure caused by non-ischemic etiologies (such as dilated cardiomyopathy, valvular heart disease, myocarditis, etc.); ② Acute myocardial infarction occurred within the last 3 months; ③ Expected lifespan \< 1 year; ④ Complicated with other severe systemic diseases; ⑤ Has a history of tumors; ⑥ Has any conditions that are unsuitable for revascularization (such as uncorrectable coagulation dysfunction, active bleeding, etc.)

Where it's running

• Beijing Chaoyang Hospital, Capital Medical University
  Beijing, China Recruiting

Study contacts

• Study coordinator: Min-Fu Yang, MD
• Email: minfuyang@126.com
• Phone: +86-10-85231356

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.