Factors affecting outcomes after endovascular treatment for large-vessel stroke

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This interventional study examines endovascular thrombectomy for acute ischemic stroke caused by large vessel occlusion. It includes adults aged 18 to 80 presenting within 24 hours, with imaging criteria to identify salvageable brain tissue in later windows. Outcomes are evaluated in relation to clinical and radiological factors to understand what influences recovery. Time-sensitive treatment and rapid diagnosis are emphasized, with emphasis on broad imaging selection criteria to minimize delays. The trial is conducted under Sohag University as the lead sponsor, at Sohag University Faculty of Medicine in Sohag, Egypt.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* General Criteria (Applicable to All Time Windows)

  * Age ≥ 18 to 80 years old.
  * Acute ischemic stroke due to large vessel occlusion (LVO) presenting within 24 hours from symptom onset or last known well. Occlusion involving one of the following vessels:
* internal carotid artery (ICA)
* M1 segment of the middle cerebral artery (MCA)
* A1 segment of the anterior cerebral artery (ACA)
* P1 segment of the posterior cerebral artery (PCA)
* Basilar artery (BA)
* V4 segment of the vertebral artery (VA)

  * National Institutes of Health Stroke Scale (NIHSS) score ≥ 6. Patients Presenting Within 0-6 Hours from Symptom Onset or Last Known Well ,
  * Alberta Stroke Program Early CT Score (ASPECTS) ≥ 6.

Patients presenting 6-24 hours from the last known well, imaging eligibility based on :

* Estimated ischemic core volume \< 70 mL.
* Ratio of critically hypoperfused tissue to ischemic core (mismatch ratio) ≥ 1.8.
* Absolute volume of potentially salvageable tissue (Diffusion to flair mismatch volume) ≥ 15 mL.

Exclusion Criteria:

* • Patients with stroke resulting from etiologies other than LVO.

  * Individuals with a history of previous strokes.
  * Hemorrhagic stroke
  * Large established infarction (e.g., ASPECTS \< 6 for patients within the early time window or imaging findings not meeting eligibility criteria in the late window).
  * Patients presenting 6-24 hours from the last known well who do not meet advanced imaging selection criteria (e.g., DEFUSE 3 or DAWN eligibility criteria).
  * Pre-stroke disability with a modified Rankin Scale (mRS) score ≥2.
  * Rapid improvement in neurological status to an NIHSS \< 6 or evidence of vessel recanalization prior to randomization.

Where it's running

• Sohag University Faculty of Medicine
  Sohag, Egypt Recruiting

Study contacts

• Study coordinator: Mohammed ahmed kassem, assistant lecturer
• Email: mohamed011152@med.sohag.edu.eg
• Phone: 00201098003153

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

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• Transcranial magnetic stimulation after thrombectomy for acute ischemic stroke

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.