Extra high-dose arm and hand training early after stroke to improve upper-limb recovery
Official title: Efficacy of High-dosage, High-intensity Rehabilitation Program on the Motor Recovery After Stroke in Subacute Patients
Run by Adi Negev-Nahalat Eran · NCT07056049 · Data updated 2026-11-12
We will try extra technology-based arm and hand training in people 1–6 weeks after stroke to help them regain upper-limb movement.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 50 (estimated) |
| Sponsor | Adi Negev-Nahalat Eran Academic / other |
| Locations | 2 sites (Ofakim and 1 other locations) |
| Status | Recruiting |
| Started | July 13, 2025 |
| Main results expected | January 15, 2027 |
| Study ends | July 15, 2027 |
| Registry record updated | July 17, 2025 |
| Trial ID | NCT07056049 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are adults (≥18) 1–6 weeks after a confirmed ischemic or hemorrhagic stroke with at least 20° of active shoulder flexion, some wrist or finger movement, ability to give informed consent, and without severe spasticity, painful shoulder, unstable medical conditions, or major communication/cognitive deficits.
✕Probably not a fit
Patients with severe spasticity or non-neural loss of range of motion, a painful shoulder that limits reaching, major cognitive or communication impairments, or unstable medical conditions are unlikely to benefit or be eligible.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This interventional program enrolls adults 1–6 weeks after an ischemic or hemorrhagic stroke who retain some active shoulder and wrist/finger movement. Participants receive additional technology-based upper-extremity training for 120 minutes per day, five days a week, for four weeks on top of usual care. Outcomes are measured at baseline and followed for a total study duration of six months to track motor recovery. The protocol targets high-dosage, high-intensity repetitive practice during the subacute period when neuroplasticity may be greatest.
Why it matters
Potential benefit: If successful, patients could regain more arm and hand function and achieve greater independence in daily activities.
How similar studies have gone: Animal studies and some human trials suggest intensive early training can improve motor recovery, but clinical evidence is not yet conclusive and results have been mixed.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Age ≥18 years * Ischemic or hemorrhagic stroke (hemispheric or brainstem) confirmed by CT or MRI * First-ever stroke or previous stroke with no upper extremity weakness * 1 week ≤ Time after stroke onset ≤ 6 weeks * Active shoulder flexion of at least 20◦ and partial wrist and/or finger active movement * Ability to provide inform consent Exclusion Criteria: * A painful shoulder limiting an active forward reach * Severe spasticity or non-neural loss of range of motion * Cognitive or communication impairments as determined by the clinical team Unstable medical conditions
Where it's running
-
Adi Negev-Nahalat Eran
Ofakim, Israel Recruiting -
Adi Negev-Nahalat Eran
Ofakim, Israel Not yet recruiting
Study contacts
- Principal investigator: Lior Shmuelof, Prof. — Ben-Gurion University of the Negev
- Study coordinator: Gil Meir
- Email: gilmeir10@gmail.com
- Phone: +972 0548340307
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.