Extended oral tranexamic acid after hip or knee replacement
Official title: Postoperative Oral Tranexamic Acid in Patients Undergoing Primary Total Joint Arthroplasty
Run by Mayo Clinic · NCT06832878 · Data updated 2026-11-12
This study tests whether continuing oral tranexamic acid after primary total joint replacement helps patients recover with better function and fewer complications.
Quick facts
| Phase | Phase 4 |
|---|---|
| Study type | Interventional |
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 101 (estimated) |
| Sponsor | Mayo Clinic Academic / other |
| Locations | 1 site (Scottsdale, Arizona) |
| Status | Recruiting |
| Started | June 1, 2026 |
| Main results expected | June 2027 |
| Study ends | June 2027 |
| Registry record updated | August 10, 2026 |
| Trial ID | NCT06832878 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults (18+) undergoing primary total joint arthroplasty for end-stage osteoarthritis, discharged on postoperative day 1, receiving spinal anesthesia, and able to provide informed consent.
✕Probably not a fit
Patients not experiencing the intended benefit may include those with contraindications to TXA, non-end-stage-osteoarthritis indications, or who are discharged later than postoperative day 1.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This phase 4 interventional trial examines an extended regimen of oral tranexamic acid given after primary total joint arthroplasty (hip or knee replacement) performed under spinal anesthesia. Researchers will compare outcomes such as patient-reported function, time to independent walking, range of motion, swelling, hemoglobin changes, and 90-day complications, readmissions, and reoperations. Eligible adults are those with end-stage osteoarthritis undergoing primary arthroplasty and discharged on postoperative day 1. Exclusion criteria include allergy to TXA, revision or non-osteoarthritis indications, general anesthesia, same-day discharge, cancer, prior VTE, anticoagulant use beyond ASA, pregnancy risk, hormonal contraception use, and retinal vascular history. Lead sponsor is Mayo Clinic, with the study conducted at Mayo Clinic in Arizona.
Why it matters
Potential benefit: If successful, patients could experience improved function and fewer postoperative complications after primary joint replacement.
How similar studies have gone: Prior studies of tranexamic acid in joint replacement have shown benefits, but this specific extended oral regimen after primary arthroplasty is being tested to confirm efficacy and safety.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria * Adults aged \> 18 years (All women of childbearing potential undergo pregnancy testing prior to THA as per our institutional protocol) * Written informed consent * Patients undergoing primary THA diagnosis of end-stage osteoarthritis * Patients receiving spinal anesthesia * Patients being discharged on postoperative day 1 Exclusion Criteria * Patients with a TXA allergy * Patients undergoing revision procedures * Patients undergoing primary THA for a diagnosis other than end-stage osteoarthritis * Patients receiving general anesthesia * Patients being discharged on the same day of surgery * Cancer patients * Patients with a history of prior VTE event * Patients on preoperative anticoagulants other than ASA * Pregnant patients (All women of child bearing potential undergo pregnancy testing prior to THA as per our institutional protocol) * Female patients who are on hormonal contraception * Patients with history of retinal vein or artery occlusion
Where it's running
-
Mayo Clinic in Arizona
Scottsdale, Arizona, United States Recruiting
Study contacts
- Principal investigator: Joshua Bingham — Mayo Clinic
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.