Exploring the role of immune cells and gut bacteria in idiopathic nephrotic syndrome
Official title: Controlled Multicenter Epidemiological Study of Peripheral Leukocyte Populations and Microbiota in Patients With Idiopathic Nephrotic Syndrome (INS)
Run by Nantes University Hospital · NCT04924712 · Data updated 2026-11-12
This study is trying to see how immune cells and gut bacteria affect people with idiopathic nephrotic syndrome during kidney problems.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 12 Years and up |
| Sex | All |
| Enrollment | 30 (estimated) |
| Sponsor | Nantes University Hospital Academic / other |
| Locations | 2 sites (Nantes, Loire-Atlantique and 1 other locations) |
| Status | Recruiting |
| Started | January 18, 2022 |
| Main results expected | January 18, 2027 |
| Study ends | January 18, 2027 |
| Registry record updated | March 3, 2026 |
| Trial ID | NCT04924712 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates for this study are patients currently experiencing a nephrotic attack with significant proteinuria.
✕Probably not a fit
Patients with a history of nephrotic syndrome flare-ups resistant to corticosteroid therapy or those currently on immunosuppressants may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This observational study investigates the relationship between immune system components, specifically B-lymphocytes and regulatory T cells, and the microbiota in patients suffering from idiopathic nephrotic syndrome (INS). It aims to measure blood immune populations and microbiota distribution during nephrotic attacks, which are characterized by significant proteinuria. The study seeks to understand the underlying mechanisms of this kidney disease, which can lead to chronic renal failure and complications post-kidney transplantation.
Why it matters
Potential benefit: If successful, this study could lead to improved understanding and management of idiopathic nephrotic syndrome, potentially reducing the frequency and severity of flare-ups.
How similar studies have gone: While the specific approach of this study is novel, previous studies have indicated a potential link between immune dysfunction and nephrotic syndrome, suggesting that exploring these connections may yield valuable insights.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria : * Patient treated in participating centers * In nephrotic attack, defined biologically by: Proteinuria \> 3g 24h or A proteinuria/creatinuria ratio \> 3 or Defined at the discretion of the clinician Non inclusion Criteria : * Patient with a history of NIS flare-ups resistant to corticosteroid therapy * Patient treated with immunosuppressant * Patient treated with corticosteroids \> 10 mg/d * Weight \<50 kg * Pregnant woman * Patient under guardianship / curatorship
Where it's running
-
Nantes University Hospital
Nantes, Loire-Atlantique, France Recruiting -
Departemental Hospital Center
La Roche-sur-Yon, France Recruiting
Study contacts
- Study coordinator: Christophe Masset
- Email: christophe.masset@chu-nantes.fr
- Phone: +33 2 76 64 39 61
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
-
Inulin Prebiotic for Perimenopausal Women with Overweight or Obesity
This study tests whether 2 weeks of inulin can affect gut and vaginal microbes, heart health, and muscle health in perimenopausal women who are overweight or obese, using a crossover design.
-
Health effects of ultra-processed foods on appetite and cardiometabolic health
This study tests whether a high ultra-processed food diet affects appetite and cardiometabolic health compared with a nutrient-matched low ultra-processed diet in adults who keep their weight stable.
-
Cranberry for gut and metabolic health in adults with overweight or obesity
This study will test whether drinking a cranberry beverage can improve blood sugar control, insulin sensitivity, blood lipids, and gut microbiota in adults with overweight or obesity who have metabolic risk factors.
-
Gut microbiota in children with suspected brain tumors
This will test whether stool samples can reveal gut microbiota differences in children aged 3–18 who are suspected of having a central nervous system (CNS) tumor.
-
Flourish: Early infant gut microbiome program for babies born by C-section
This project tests whether microbiome analysis, education, and personalized recommendations can improve gut bacteria and reduce early immune-related markers in babies born by C-section aged 0–3 months.
-
Epilepsy and gut and mouth bacteria: linking microbiota to seizure medicine response
This project will test whether differences in gut and mouth bacteria are linked to epilepsy type and change how well seizure medicines work in people newly diagnosed with epilepsy compared with healthy volunteers.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.