Exploring the role of IL-23 in spondyloarthritis

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study investigates the role of interleukin-23 (IL-23) in chronic inflammatory diseases, specifically focusing on spondyloarthritis (SpA). It aims to understand how IL-23 affects gene expression and cytokine production in T lymphocytes from SpA patients, correlating these effects with patient genotypes. Additionally, the study will characterize immune cell populations in blood and synovial fluid from patients with peripheral SpA and identify cells expressing the IL-23 receptor. Participants will be recruited from multiple hospitals in Paris and Reims, and will be divided into groups based on their specific type of SpA.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Age : Adults (\>18 years)
* Satisfying ASAS diagnostic criteria for SpA
* Patient has active disease, defined by the presence of active synovitis, tendinitis, or dactylitis or significant inflammatory pain of the spine, judged by the examining clinician to be due to SpA.
* Informed consent signed
* Beneficiary of health insurance, except for the AME

Only for patients of Group 1 • Patient is naïve to biological therapies

Only for patients of Group 2

* Patient is affected by peripheral SpA (ASAS criteria) or psoriatic arthritis, with inflammation of peripheral joints
* Patient requires aspiration, as part of standard care

Non inclusion criteria:

* Patient is minor
* Patient is pregnant or breastfeeding
* Patient is immunocompromised
* Patient has received biological therapy with 2 or more biologics
* Patient is receiving corticosteroid treatment \> 10 mg per day
* Patient is under legal protection, curators, guardianship
* Patient refuses consent
* Previous history of alcoholism, drug addiction, psychological problems, severe concomitant conditions that could invalidate the patient's consent or limit the patient's compliance to the treatment protocol.
* Beneficiary of the AME

Only for group 1

• Patient has received biological therapy

Where it's running

• Hôpital Cochin, AP-HP - Department of Dermatology B
  Paris, France Recruiting
• Hôpital Saint-Antoine, AP-HP - Service de Rhumatologie
  Paris, France Recruiting
• Hôpital Henri-Mondor, AP-HP - Service de Rhumatologie
  Créteil, France Not yet recruiting
• Hôpital Maison Blanche - Service de Rhumatologie
  Reims, France Not yet recruiting

Study contacts

• Study coordinator: Lars ROGGE, Dr
• Email: lars.rogge@pasteur.fr
• Phone: +33140613822

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.