Exploring the molecular causes of cataracts
The Molecular Pathogenesis Study of Cataract
Eye & ENT Hospital of Fudan University · NCT05682001
This study is trying to understand the molecular causes of cataracts by looking at lens samples from people with diabetes and age-related cataracts to see how certain RNA changes might affect their development.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 150 (estimated) |
| Ages | 18 Years to 90 Years |
| Sex | All |
| Sponsor | Eye & ENT Hospital of Fudan University (other) |
| Locations | 1 site (Shanghai, Shanghai) |
| Trial ID | NCT05682001 on ClinicalTrials.gov |
What this trial studies
This study investigates the molecular pathogenesis of cataracts by collecting anterior lens capsules from patients with diabetic cataracts and age-related cataracts, as well as from transparent cadaveric eyes. It employs M6A epitranscriptomic microarray techniques to analyze altered m6A modifications and identify differentially expressed mRNAs. The research aims to predict the role of dysregulated m6A modification levels through various bioinformatics analyses, including Gene Ontology and KEGG pathway enrichment. Additionally, real-time polymerase chain reaction will be used to assess the expression levels of RNA methyltransferases, demethylases, and readers.
Who should consider this trial
Good fit: Ideal candidates for this study are patients with diabetic cataracts who have undergone cataract surgery.
Not a fit: Patients with other eye diseases or those who have undergone other eye surgeries may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to a better understanding of cataract development and potential new treatment options.
How similar studies have performed: While this approach is innovative, similar studies exploring molecular mechanisms of cataracts have shown promise in understanding the condition.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * diabetic cataract * underwent cataract surgery Exclusion Criteria: * Combined with other eye diseases * underwent other eye surgery
Where this trial is running
Shanghai, Shanghai
- Eye & ENT Hospital of Fudan University — Shanghai, Shanghai, China (RECRUITING)
Study contacts
- Principal investigator: Jin Yang, PhD — Eye & ENT Hospital
- Study coordinator: Lei Cai, MD
- Email: clyc0318@126.com
- Phone: 13816956828
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions: Cataract, Pathogenesis