Exploring the microbiome in burn wounds using advanced sequencing techniques

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This investigation aims to enhance our understanding of the microbiome present in burn wounds and its influence on treatment outcomes and complications. By comparing traditional wound cultures with next-generation sequencing technology, the study seeks to uncover the complex interactions between microbial colonization and wound healing processes. The research will involve adult patients with partial or full thickness burns who are undergoing operative intervention, allowing for the collection of relevant biospecimens. The findings could provide insights into how the microbiome affects infection rates and overall patient prognosis.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* All adult patients (18 years of age and greater) admitted to or consulted by the Acute Burn Surgery service with a diagnosis of a partial thickness or full thickness burn wound determined by the Acute Burn Surgery service to be appropriate for operative intervention. We will include patients 18 years of age and older of any gender, race, prior therapy, or pre-existing medical condition. We will also include subjects in special classes, including pregnant women and cognitively impaired persons.

Exclusion Criteria:

* Children (less than 18 years of age) will be excluded. Patients who do not undergo operative therapy or patients whose operative therapy does not involve tangential excision of burn wounds will also not be eligible for inclusion by virtue of not being able to provide appropriate biospecimens. Patients whose burn wounds are isolated to the genitalia and perineum will be excluded from the study. For patients who have multiple burn wounds including those to the genitalia and perineum, it should be noted that excised tissues from the genitalia and perineum are not eligible for inclusion to the Burn Wound Data/Bio-Repository. Finally, patients whose operative intervention results in less than a total of 4 grams of discarded tissue will be excluded due to insufficient specimen for proper tissue analysis. Any tissue allocated for pathology or that has already been physically discarded into a trash receptacle will not be eligible for inclusion in the Burn Wound Data/Bio-Repository. We will also exclude prisoners from this study.

Where it's running

• University of Texas Medical Branch
  Galveston, Texas, United States Recruiting

Study contacts

• Principal investigator: Steven E Wolf, MD — University of Texas
• Study coordinator: Steven E Wolf, MD
• Email: swolf@utmb.edu
• Phone: 12107870507

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.