Exploring the link between rheumatoid arthritis severity and cognitive function in older adults
The Mediating Effect of Nociplastic Pain on the Relationship Between Rheumatoid Arthritis Severity and Cognition in Geriatric Patients: A Cross-Sectional Study
Ahram Canadian University · NCT05934721
This study is trying to see if older adults with more severe rheumatoid arthritis have more trouble with thinking and memory because of increased pain sensitivity.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 100 (estimated) |
| Ages | 65 Years to 90 Years |
| Sex | All |
| Sponsor | Ahram Canadian University (other) |
| Locations | 1 site (Al Ḩayy Ath Thāmin, Giza) |
| Trial ID | NCT05934721 on ClinicalTrials.gov |
What this trial studies
This observational study investigates how nociplastic pain may influence the relationship between the severity of rheumatoid arthritis (RA) and cognitive impairment in elderly patients aged 65 to 90 years. It aims to recruit 100 participants with long-standing RA to assess their disease severity, cognitive function, and levels of pain sensitization. The hypothesis is that patients with more severe RA will exhibit worse cognitive function, potentially mediated by higher levels of nociplastic pain.
Who should consider this trial
Good fit: Ideal candidates are elderly individuals aged 65-90 years with a long-standing diagnosis of rheumatoid arthritis.
Not a fit: Patients with other inflammatory arthritides, dementia, severe depression, or recent corticosteroid or immunosuppressant use may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could provide insights into managing cognitive impairment in elderly patients with rheumatoid arthritis.
How similar studies have performed: While the specific relationship between nociplastic pain and cognitive function in RA is less explored, similar studies have indicated that chronic pain can impact cognitive health, suggesting potential relevance.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Age 65-90 years * diagnosed with RA for 10-30 years * meet ACR/EULAR 2010 criteria Exclusion Criteria: * Other inflammatory arthritides * dementia * severe depression * recent corticosteroid or immunosuppressant use
Where this trial is running
Al Ḩayy Ath Thāmin, Giza
- Outpatient clinic of faculty of physical therapy, Ahram Canadian University — Al Ḩayy Ath Thāmin, Giza, Egypt (RECRUITING)
Study contacts
- Study coordinator: Mohamed M ElMeligie, Ph.d
- Email: mohamed.elmeligie@acu.edu.eg
- Phone: +201064442032
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions: Rheumatoid Arthritis, Rheumatic Diseases, Rheumatoid Polyarthritis