Exploring the link between fat soluble vitamins and non-alcoholic fatty liver disease
Study on the Correlation Between Fat Soluble Vitamins and Non-alcoholic Fatty Liver Disease
This study is trying to see if the levels of fat-soluble vitamins A, D, and E in the blood are linked to the risk of developing non-alcoholic fatty liver disease in a group of 4,000 patients.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 4000 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | First Affiliated Hospital of Zhejiang University Academic / other |
| Locations | 1 site (Hangzhou, Zhejiang) |
| Trial ID | NCT06512701 on ClinicalTrials.gov |
What this trial studies
This observational study aims to investigate the correlation between serum levels of fat soluble vitamins (A, D, and E) and the risk of non-alcoholic fatty liver disease (NAFLD) in a cohort of 4000 patients. Participants will be categorized into NAFLD and non-NAFLD groups based on abdominal ultrasound results, and their vitamin levels will be compared to identify any significant relationships. The findings could provide valuable insights for nutritional management and clinical strategies for NAFLD patients.
Who should consider this trial
Good fit: Ideal candidates include adults aged 18 and older who have been diagnosed with NAFLD.
Not a fit: Patients with acute or chronic infections, severe comorbidities, or those who have recently taken vitamin supplements may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could enhance understanding of nutritional factors influencing NAFLD, potentially leading to improved management strategies for patients.
How similar studies have performed: While there is ongoing research into the relationship between vitamins and liver health, this specific correlation in the context of NAFLD remains underexplored, making this study a novel investigation.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: 1. Age ≥ 18 years old, both male and female; 2. Voluntarily participate in this study and sign an informed consent form; 3. Diagnosed NAFLD through abdominal ultrasound; Exclusion Criteria: 1. Acute and chronic infections, severe cardiovascular and cerebrovascular diseases, respiratory system diseases, urinary system diseases, rheumatic diseases, tumors, and pituitary dysfunction; Or have hepatitis B, hepatitis C virus, or acquired immunodeficiency syndrome; 2. Surgery was performed within 6 months, and blood donation, transfusion, or significant blood loss occurred within 4 months; 3. Have taken vitamin supplements within 2 weeks; 4. Women are in pregnancy, lactation, or within one year after childbirth; 5. Alcohol abuse (alcohol intake ≥ 140 g/week for males and ≥ 70 g/week for females) 6. The serum creatinine (SCr) exceeds twice the following abnormal values, with the standard of abnormal values being: male (20-59 years old)\>97 μ mol/L, male (60-79 years old)\>111 μ mol/L; Female (20-59 years old)\>73 μ mol/L, female (60-79 years old)\>81 μ mol/L.
Where this trial is running
Hangzhou, Zhejiang
- First Affiliated Hospital of Zhejiang University — Hangzhou, Zhejiang, China (Recruiting)
Study contacts
- Principal investigator: Zhong Liu, MD — First Affiliated Hospital of Zhejiang University
- Study coordinator: Zhong Liu, MD
- Email: liuzhongzheyi@zju.edu.cn
- Phone: +86 13957104885
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.