Exploring the link between decreased ovarian reserve and early miscarriages
Is Decreased Ovarian Reserve Related to an Increased Number of Previous Early Miscarriages? A Prospective Observational Study
This study is trying to see if having a lower number of healthy eggs is linked to early miscarriages in women, to help improve fertility treatments.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 2059 (estimated) |
| Sex | Female |
| Sponsor | ART Fertility Clinics LLC Academic / other |
| Drugs / interventions | chemotherapy, radiation |
| Locations | 3 sites (Abu Dhabi, Abu Dhabi Emirate and 2 other locations) |
| Trial ID | NCT05969574 on ClinicalTrials.gov |
What this trial studies
This observational study investigates the correlation between decreased ovarian reserve (LOR) and a history of early miscarriages in women. By assessing the prevalence of LOR in populations with specific reproductive histories, including recurrent pregnancy loss and ectopic pregnancies, the study aims to understand how LOR affects fertility outcomes. Participants will undergo transvaginal ultrasound and blood tests to measure AMH levels, which will help inform clinical decisions regarding fertility treatments. The findings could lead to improved success rates in infertility treatments and reduced anxiety for participants seeking to become parents.
Who should consider this trial
Good fit: Ideal candidates include women with at least one previous pregnancy who are being assessed at ART Fertility Clinics.
Not a fit: Patients with severe male factor infertility, significant uterine abnormalities, or those with a BMI over 40 may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could enhance understanding of fertility issues and improve treatment strategies for women with decreased ovarian reserve.
How similar studies have performed: While the correlation between ovarian reserve and miscarriage has been explored, this specific approach focusing on reproductive history and PGT-A outcomes is relatively novel.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: 1\. All participants with at least 1 previous pregnancy, who are assessed in one of our clinics (ART Fertility Clinics Abu Dhabi, Al Ain, Dubai) Exclusion Criteria: 1. Severe male factor (azoospermia, cryptozoospermia, severe oligoasthenoteratozoospermia (OAT)) 2. Severe Endometriosis and adenomyosis based on positive anamnesis or ultrasound performed in our center during the first consultation 3. Uterine abnormalities (e.g. fibroids, different degrees of uterine septum), diagnosed by ultrasound 4. History of ovarian surgery, chemotherapy, or radiation therapy 5. Known genetic disorder or chromosomal abnormality 6. BMI \>40Kg/m2 7. Currently using hormonal contraception or hormone replacement therapy
Where this trial is running
Abu Dhabi, Abu Dhabi Emirate and 2 other locations
- ART Fertility Clinics LLC — Abu Dhabi, Abu Dhabi Emirate, United Arab Emirates (Recruiting)
- ART Fertility Clinics Al Ain — Al Ain City, United Arab Emirates (Recruiting)
- ART Fertility Clinics Dubai — Dubai, United Arab Emirates (Recruiting)
Study contacts
- Principal investigator: Laura Melado, PhD — ART Fertility Clinics LLC
- Study coordinator: Barbara Lawrenz, PhD
- Email: barbara.lawrenz@artfertilityclinics.com
- Phone: +971 800 337845489
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.