Exploring the link between decreased ovarian reserve and early miscarriages
Official title: Is Decreased Ovarian Reserve Related to an Increased Number of Previous Early Miscarriages? A Prospective Observational Study
Run by ART Fertility Clinics LLC · NCT05969574 · Data updated 2026-11-12
This study is trying to see if having a lower number of healthy eggs is linked to early miscarriages in women, to help improve fertility treatments.
Quick facts
| Study type | Observational |
|---|---|
| Sex | Women only |
| Enrollment | 2059 (estimated) |
| Sponsor | ART Fertility Clinics LLC Academic / other |
| Drugs / interventions | chemotherapy, radiation |
| Locations | 3 sites (Abu Dhabi, Abu Dhabi Emirate and 2 other locations) |
| Status | Recruiting |
| Started | September 9, 2023 |
| Main results expected | December 31, 2026 |
| Study ends | December 31, 2026 |
| Registry record updated | June 25, 2026 |
| Trial ID | NCT05969574 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates include women with at least one previous pregnancy who are being assessed at ART Fertility Clinics.
✕Probably not a fit
Patients with severe male factor infertility, significant uterine abnormalities, or those with a BMI over 40 may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This observational study investigates the correlation between decreased ovarian reserve (LOR) and a history of early miscarriages in women. By assessing the prevalence of LOR in populations with specific reproductive histories, including recurrent pregnancy loss and ectopic pregnancies, the study aims to understand how LOR affects fertility outcomes. Participants will undergo transvaginal ultrasound and blood tests to measure AMH levels, which will help inform clinical decisions regarding fertility treatments. The findings could lead to improved success rates in infertility treatments and reduced anxiety for participants seeking to become parents.
Why it matters
Potential benefit: If successful, this study could enhance understanding of fertility issues and improve treatment strategies for women with decreased ovarian reserve.
How similar studies have gone: While the correlation between ovarian reserve and miscarriage has been explored, this specific approach focusing on reproductive history and PGT-A outcomes is relatively novel.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: 1\. All participants with at least 1 previous pregnancy, who are assessed in one of our clinics (ART Fertility Clinics Abu Dhabi, Al Ain, Dubai) Exclusion Criteria: 1. Severe male factor (azoospermia, cryptozoospermia, severe oligoasthenoteratozoospermia (OAT)) 2. Severe Endometriosis and adenomyosis based on positive anamnesis or ultrasound performed in our center during the first consultation 3. Uterine abnormalities (e.g. fibroids, different degrees of uterine septum), diagnosed by ultrasound 4. History of ovarian surgery, chemotherapy, or radiation therapy 5. Known genetic disorder or chromosomal abnormality 6. BMI \>40Kg/m2 7. Currently using hormonal contraception or hormone replacement therapy
Where it's running
-
ART Fertility Clinics LLC
Abu Dhabi, Abu Dhabi Emirate, United Arab Emirates Recruiting -
ART Fertility Clinics Al Ain
Al Ain City, United Arab Emirates Recruiting -
ART Fertility Clinics Dubai
Dubai, United Arab Emirates Recruiting
Study contacts
- Principal investigator: Laura Melado, PhD — ART Fertility Clinics LLC
- Study coordinator: Barbara Lawrenz, PhD
- Email: barbara.lawrenz@artfertilityclinics.com
- Phone: +971 800 337845489
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.