Exploring the impact of diet on gum inflammation
Experimental Gingivitis in Omnivores and Vegetarians/Vegans. The Role of Diet in Periodontal Inflammation: A Controlled Clinical Study
This study tests if following a vegan or vegetarian diet can help reduce gum inflammation compared to an omnivorous diet in healthy people with no history of gum disease.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 44 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | G. d'Annunzio University Academic / other |
| Locations | 1 site (Chieti, CH) |
| Trial ID | NCT05864768 on ClinicalTrials.gov |
What this trial studies
This study investigates how different diets, specifically vegan/vegetarian versus omnivorous, affect periodontal inflammation and health. It aims to understand the role of dietary choices in influencing the severity of periodontal diseases by examining their effects on the immune response and tissue repair mechanisms. Participants will be monitored for their periodontal health while adhering to their respective diets over a specified period. The study focuses on individuals with optimal systemic health and no history of periodontal disease.
Who should consider this trial
Good fit: Ideal candidates are healthy individuals who have been following either a vegan/vegetarian or omnivorous diet for at least a year and have no history of periodontal disease.
Not a fit: Patients with existing periodontal disease or systemic health issues, such as cardiovascular diseases or diabetes, may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could provide insights into dietary recommendations that may help protect against periodontal diseases.
How similar studies have performed: While the specific dietary impact on periodontal health is less explored, similar studies have shown promising results in the role of diet in managing other inflammatory conditions.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Optimal systemic health conditions * Non-Smoking * Absence of cardio-vascular pathologies * Absence of pulmonary pathologies * Non-diabetic * Not pregnant * FMPS \<20% * FMBS \<20% * Omnivorous or vegan/vegetarian diet for at least a year * Absence of periodontitis Exclusion Criteria: * Smokers * Presence of systemic pathologies * Presence of cardio-vascular disease * Presence of periodontitis * FMPS\>20% * FMBS\>20% * Pregnant women * Presence of blood pathologies * Taking medicines (hydantoins, nifedipine or cyclosporine) * Taking oral contraceptives * Bacterial, viral or fungal infections * Idiopathic gingival fibromatosis * Mucocutaneous disorders * Allergic reactions to toothpastes and mouthwashes
Where this trial is running
Chieti, CH
- G. D'Annunzio University — Chieti, Ch, Italy (Recruiting)
Study contacts
- Principal investigator: Michele Paolantonio, MD; DDS — University G. D'Annunzio Chieti-Pescara
- Study coordinator: Michele Paolantonio, MD; DDS
- Email: mpaolantonio@unich.it
- Phone: +393395204073
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.