Exploring the genetic factors of hearing loss in Turner Syndrome
Genetic and Epigenetic Background of Inner Ear Dysfunction in Turner Syndrome
This study is trying to find out how genetics might affect hearing loss in people with Turner Syndrome to help develop new treatments.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 150 (estimated) |
| Ages | 18 Years to 60 Years |
| Sex | Female |
| Sponsor | Gødstrup Hospital Academic / other |
| Locations | 1 site (Herning) |
| Trial ID | NCT06507007 on ClinicalTrials.gov |
What this trial studies
This observational study aims to investigate the genetic and epigenetic factors associated with sensorineural hearing loss in individuals with Turner Syndrome. By examining DNA methylation patterns and RNA expression profiles, the study seeks to identify potential links between these genetic markers and inner ear dysfunction. Participants will undergo a series of tests, including ear examinations, hearing assessments, balance evaluations, blood tests, and imaging scans, to gather comprehensive data on their inner ear health. The ultimate goal is to uncover insights that could lead to innovative treatments for hearing loss.
Who should consider this trial
Good fit: Ideal candidates for this study are individuals aged 18 to 60 with Turner Syndrome who experience sensorineural hearing loss.
Not a fit: Patients with serious medical disorders, neurological or psychiatric conditions, or those taking medications affecting inner ear function may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to new treatment options that may reduce or eliminate the need for hearing aids in patients with Turner Syndrome.
How similar studies have performed: While the specific approach of this study is novel, previous research has indicated that exploring genetic and epigenetic factors can yield valuable insights into hearing loss.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * age between 18 and 60 years old Exclusion Criteria: * Contraindications for the MRI or CBCT * Serious medical disorders * Neurological or psychiatric disorders of any kind * Use of medication that is known to influence inner ear function * Medical history with dizziness or hearing problems (controls only)
Where this trial is running
Herning
- ENT department of Gødstrup Hospital — Herning, Denmark (Recruiting)
Study contacts
- Principal investigator: Therese Ovesen, Prof — University Clinic of Flavour, Balance and Sleep
- Study coordinator: Louise Hill-Madsen, MD
- Email: lohill@rm.dk
- Phone: 20282635
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.