Exploring the Enteric Nervous System in Spinal Cord Injury Patients

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This clinical trial aims to investigate the enteric nervous system (ENS) and the intestinal epithelial barrier (IEB) in patients with spinal cord injuries. It will involve colonic biopsies to assess various parameters such as intestinal permeability, serotonin production, and the remodeling of the colonic mucosa. The study seeks to correlate these findings with the severity of neurological impairment and identify potential therapeutic targets for future treatments. By understanding the ENS and IEB in this patient population, the research hopes to provide insights that could lead to improved management of digestive dysfunctions associated with spinal cord injuries.

Why it matters

Who can join: the full rules

Inclusion Criteria for patient with spinal cord injury:

Patient with signed consent Patient over 18 and under 80 years of age Patient with acquired traumatic or non-traumatic spinal cord injury Patient with an indication for colonoscopy or rectosigmoidoscopy at the Nantes University Hospital Gastroenterology Department Eligible for French social security Patient enrolled in the COSCINUS cohort

Inclusion criteria for control group:

Subject with signed consent Subject over 18 and under 80 years of age Subject free of any neurological pathology, with an indication for screening or preventive colonoscopy in the context of a personal or family history of polyps, or familial colon cancer, in the gastroenterology department of the Nantes University Hospital.

Exclusion Criteria for patients with spinal cord injury:

Patients in emergency situations, deprived of liberty, or not covered by the social security system Patient under legal protection Patient suffering from an inflammatory digestive disease Patient on anticoagulant therapy with no possibility of discontinuation or relay Patient with contraindications to colonoscopy/rectosigmoidoscopy Pregnant or breast-feeding patient

Exclusion criteria for control group:

Treatment with anticoagulants Treatment with antiaggregants Subject with a coagulation disorder Subject having finally an abnormal colonoscopy (discovery of any pathology other than one or more benign polyps)

Where it's running

• CHU de Nantes service MPR
  Nantes, France Recruiting
• CHU de Nantes service de gastroentérologie
  Nantes, France Not yet recruiting

Study contacts

• Study coordinator: Chloé LEFEVRE
• Email: chloe.lefevre@chu-nantes.fr
• Phone: 02 40 84 60 66

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.