Exploring the effects of gut bacteria on irritable bowel syndrome
Pathophysiological Effects of Persistently Colonized Microbiome on Irritable Bowel Syndrome
This study is testing how the gut bacteria of people with irritable bowel syndrome (IBS) is different from those without IBS to help find better treatments.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 30 (estimated) |
| Ages | 18 Years to 50 Years |
| Sex | All |
| Sponsor | Second Affiliated Hospital, School of Medicine, Zhejiang University Academic / other |
| Locations | 1 site (Hangzhou, Zhejiang) |
| Trial ID | NCT06013410 on ClinicalTrials.gov |
What this trial studies
This clinical trial investigates how the microbiome, specifically the biofilm, differs between patients with irritable bowel syndrome (IBS) and healthy individuals. It aims to identify variations in microbiome composition and metabolic products through colonoscopy and gut mucosal biopsy samples. By comparing these factors between IBS patients and healthy controls, the study seeks to uncover disease-specific patterns that could inform future treatments.
Who should consider this trial
Good fit: Ideal candidates for this study are adults diagnosed with type IV irritable bowel syndrome who have not undergone abdominal surgery.
Not a fit: Patients under 18, those with major diseases, or individuals with a history of severe gastrointestinal or cardiac diseases may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to new insights into the role of gut bacteria in IBS, potentially guiding more effective treatments.
How similar studies have performed: While the specific approach of this study may be novel, previous research has indicated that understanding the microbiome's role in IBS could yield significant insights.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * IBS patients with IV type; no abdominal surgery; Exclusion Criteria: * age \<18 y; * major disease; * alcoholic addicted; * antibiotic use in past 3 months; * severe gastrointestinal disease * severe cardiac disease; * pregnant; * ICU in past 1 year; * vegeterian; * immune disease (SLE etc.) * mental disease;
Where this trial is running
Hangzhou, Zhejiang
- 2ndAffiliated Hospital, School of Medicine, Zhejiang University — Hangzhou, Zhejiang, China (Recruiting)
Study contacts
- Study coordinator: Wei Wei
- Email: wwze@zju.edu.cn
- Phone: 15267175186
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.