Exploring interstitial fluid in septic shock patients
Official title: Interstitial Fluid Composition in Patients with Septic Versus Non-septic Shock: an Exploratory Pilot Study
Run by Centre Hospitalier Universitaire Dijon · NCT05039151 · Data updated 2026-05-14
This study is no longer in our active list. It may have stopped recruiting or finished. The details below are as of 2026-05-14 and are kept for reference. Check ClinicalTrials.gov for its current status, or see similar studies below.
This study looks at the fluid in the body of patients with septic shock to see how it differs from those without sepsis, hoping to find better ways to manage their treatment.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 25 (estimated) |
| Sponsor | Centre Hospitalier Universitaire Dijon Academic / other |
| Locations | 1 site (Dijon) |
| Trial ID | NCT05039151 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates for this study are adults aged 18 and older who are under mechanical ventilation and sedation and have been diagnosed with septic shock within 24 hours of admission.
✕Probably not a fit
Patients who have conditions mimicking sepsis or those with disseminated intravascular coagulation are unlikely to benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This observational pilot study aims to investigate the composition of interstitial fluid in patients experiencing septic shock compared to those without sepsis. By analyzing interstitial fluid and blood samples, the study seeks to understand the fluid management challenges associated with septic shock, which is a critical condition often leading to intensive care unit admissions. The research focuses on the role of interstitial fluid in the body's response to severe infections and its implications for patient prognosis. The findings could provide insights into better management strategies for fluid resuscitation in septic patients.
Why it matters
Potential benefit: If successful, this study could lead to improved fluid management strategies for patients with septic shock, potentially enhancing their recovery and survival rates.
How similar studies have gone: While the specific approach of analyzing interstitial fluid in septic shock is exploratory, similar studies have indicated the importance of fluid management in critical care settings.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: COMMON INCLUSION CRITERIA * Patient under mechanical ventilation and sedation * Patient and/or trusted person (health care proxy) or close relative who has given their oral consent after being informed, * Age ≥ 18 years old, INCLUSION CRITERIA FOR THE SEPTIC SHOCK GROUP * Diagnosis within 24 hours of admission of septic shock as defined by : * A probable or confirmed infection * And a SOFA score ≥ 2 * And the need to introduce vasopressors to obtain a MAP ≥ 65 mmHg despite adequate vascular filling * And an arterial lactate \> 2 mmol/l * Norepinephrine dose greater than 0.1 μg/kg/min * Septic shock present for less than 48 hours INCLUSION CRITERIA FOR THE CONTROL GROUP - Absence of sepsis and shock from any cause within 2 months prior to inclusion Exclusion Criteria: * Disseminated intravascular coagulation (DIC) with haemorrhagic syndrome * Acute condition that can mimic sepsis : * Acute pancreatitis without signs of superinfection * Metformin Intoxication * Patient with an unfavourable prognosis within 24 hours * Patient under legal protection (safeguard of justice, guardianship or tutelage) * Pregnant or breastfeeding women * Patient not affiliated to national health insurance
Where it's running
-
Chu Dijon Bourgogne
Dijon, France Recruiting
Study contacts
- Study coordinator: Jean-Pierre QUENOT
- Email: jean-pierre.quenot@chu-dijon.fr
- Phone: 03 80 29 36 85
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
-
Adjunctive Fludrocortisone in Septic Shock on Hydrocortisone
In septic shock, this trial tests whether adding fludrocortisone (50 mcg or 100 mcg daily) to hydrocortisone improves survival and recovery compared with placebo.
-
Non-invasive hemodynamic guidance for sepsis care on medical wards
This trial tests whether guiding fluid and vasopressor therapy for sepsis using non-invasive hemodynamic measurements works better than standard care.
-
Reducing Endotoxin Burden in Septic Shock Patients on CRRT with the oXiris Filter
This trial tests whether using the oXiris hemofilter during continuous kidney replacement helps lower endotoxin levels in adults with septic shock who need CRRT.
-
Personalized Fluid Resuscitation in the Emergency Department
This pilot test checks if a quick, non-invasive stroke-volume assessment can help ED doctors tailor IV fluids for septic patients with low blood pressure.
-
Discordance between capillary refill time and oxygen use in septic shock
This study tests whether some septic shock patients can have a normal capillary refill time but still lack tissue oxygen use, to see if that mismatch relates to 28-day survival.
-
Targeting upper-normal magnesium to see if norepinephrine needs drop in septic shock
This trial tests whether keeping magnesium levels at the upper end of normal can reduce the amount and duration of norepinephrine needed in adults with septic shock.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.