Exploring imaging techniques for diagnosing degenerative dementia

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study aims to establish a longitudinal cohort of patients with Alzheimer's disease and other dementias by utilizing multimodal imaging and molecular imaging techniques. It will build a comprehensive database that includes neuroimaging, biological, and digital markers to investigate the mechanisms, diagnosis, evaluation, and prognosis of dementia. The study employs convolutional neural networks to analyze imaging characteristics and develop early prediction models for different dementia subtypes. Additionally, it will assess the diagnostic efficacy of new imaging probes through advanced imaging techniques and follow-up on patients with mild cognitive impairment.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Patients aged ≥50 and ≤85 years old, male or female;
* Meet the diagnostic criteria for dementia or MCI;
* Neuropsychological score: MMSE 15-28 points, CDR ≤ 1 point; ④ Patients and their families are informed and sign the informed consent form

Exclusion Criteria:

* The presence of other neurological diseases that may cause brain dysfunction (such as depression, brain tumors, Parkinson's disease, metabolic encephalopathy, encephalitis, multiple sclerosis, epilepsy, brain trauma, normal intracranial pressure hydrocephalus, etc.);
* The presence of other systemic diseases that may cause cognitive impairment (such as liver dysfunction, renal dysfunction, thyroid dysfunction, severe anemia, folic acid or vitamin B12 deficiency, syphilis, HIV infection, alcohol and drug abuse, etc.);
* Suffering from a disease that makes it impossible to cooperate with cognitive examinations;
* The presence of contraindications to MRI;
* The presence of mental and neurological retardation;
* Refusing to draw blood;
* Refusing to sign the informed consent form.

Where it's running

• Chinese People's Liberation Army General Hospital
  Beijing, Beijing Municipality, China Recruiting
• First Affiliated Hospital of Zhejiang University School of Medicine
  Hanzhong, Hangzhou, China Recruiting
• Cangzhou Hospital of Integrated Traditional Chinese and Western Medicine
  Cangzhou, Hebei, China Recruiting
• The Second Hospital of Hebei Medical University
  Shijiazhuang, Hebei, China Recruiting
• Qilu Hospital of Shandong University, Qingdao Branch
  Qingdao, Shandong, China Recruiting
• Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine
  Shanghai, Shanghai Municipality, China Recruiting

Study contacts

• Principal investigator: Gang Wang, PhD. MD. — RenJi Hospital
• Study coordinator: Jintao Wang
• Email: jt_wang@sjtu.edu.cn
• Phone: 18221457023

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.