Exploring how the body processes plant compounds from coffee and other foods
Official title: Investigation of in Vivo Endogenous and/or Exogenous Production of Phenolic Metabolites Using (un)Targeted Metabolomics
Run by University of Parma · NCT06028659 · Data updated 2026-11-12
This study is testing how healthy adults process plant compounds found in coffee and other foods to see how it affects their health.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 20 Years to 40 Years |
| Sex | All |
| Enrollment | 30 (estimated) |
| Sponsor | University of Parma Academic / other |
| Locations | 1 site (Parma, PR) |
| Status | Recruiting |
| Started | October 25, 2023 |
| Main results expected | June 30, 2025 |
| Study ends | June 30, 2025 |
| Registry record updated | April 8, 2025 |
| Trial ID | NCT06028659 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are healthy adults aged 20-40 who regularly consume coffee.
✕Probably not a fit
Patients with metabolic, cardiovascular, renal, digestive diseases, or those with autoimmune disorders may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This study investigates how healthy adults metabolize (poly)phenols, which are plant compounds found in foods like coffee. It involves a randomized cross-over design where participants will consume coffee and water over five days in two different arms. The goal is to understand individual variability in the metabolism of these compounds and their potential health benefits. Participants will be closely monitored, and their personal data will be collected while ensuring privacy through pseudoanonymization.
Why it matters
Potential benefit: If successful, this study could enhance our understanding of how dietary (poly)phenols contribute to health, potentially leading to improved dietary recommendations.
How similar studies have gone: Other studies have shown promising results in understanding the health benefits of (poly)phenols, making this approach both relevant and potentially impactful.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Apparently healthy adults, * Age 20-40 years old, * Body mass index (BMI) between 18-28, * Regular coffee consumers (at least 1 cup a day). Exclusion Criteria: * Clinical diagnosis of metabolic diseases, * Clinical diagnosis of cardiovascular diseases, * Clinical diagnosis of renal diseases, * Clinical diagnosis of digestive diseases, * Immunodeficiency * Autoimmune diseases (other than well-compensated hypothyroidism), * Mental disorders * Regular use of medication (except birth-control pills and hormone replacement therapies), * Use of antibiotics in the last month prior to enrollment, * Food allergies or intolerances, * Pregnancy * Lactation
Where it's running
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University of Parma - Plesso Biotecnologico Integrato
Parma, Pr, Italy Recruiting
Study contacts
- Principal investigator: Pedro M Mena Parreño, PhD — University of Parma
- Study coordinator: Pedro M Mena Parreño, PhD
- Email: pedromiguel.menaparreno@unipr.it
- Phone: +393288087332
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.