Exploring how different diets affect food preferences and intake in people with varying weights
Hormonal Control of Energy and Macronutrient Intake in Obesity
This study is testing how different diets, focusing on carbs and proteins, affect what people with different weights prefer to eat and how much they eat.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 45 (estimated) |
| Ages | 18 Years to 45 Years |
| Sex | All |
| Sponsor | Steno Diabetes Center Copenhagen Academic / other |
| Locations | 1 site (Herlev, Denmark) |
| Trial ID | NCT06752967 on ClinicalTrials.gov |
What this trial studies
The MEMORY study investigates how specific macronutrient compositions, such as carbohydrates and proteins, influence food preferences and intake across individuals with different body mass indices (BMIs). In this randomized cross-over study, 45 participants aged 18-45 will consume either a carbohydrate or protein liquid meal during two test visits, followed by an ad libitum buffet to assess energy intake. Clinical assessments, blood samples, and questionnaires will also be conducted to gather comprehensive data on appetite and food choices. The study aims to understand the concept of 'food memory' and its implications for obesity management.
Who should consider this trial
Good fit: Ideal candidates are adults aged 18-45 with a BMI ranging from 18.5 to 39.9 kg/m².
Not a fit: Patients with eating disorders, significant medical issues, or those on medications affecting appetite may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could provide insights into dietary strategies that help manage obesity and improve eating behaviors.
How similar studies have performed: While the concept of food memory is being explored, this specific approach to examining macronutrient effects on appetite and intake is relatively novel.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Age 18-45 years * For women: Regular menstruation * BMI-range 18.5-39.9 kg/m\^2 Exclusion Criteria: * Not able or willing to eat or drink the test meals because of e.g., allergy or intolerance * Daily smoking * For women: Pregnancy / planned pregnancy (within the study period) / lactating * Self-reported history of an eating disorder * Self-reported weight change (kg) within two months prior to inclusion * HbA1c ≥48 mmol/mol * Treatment with antidepressants * Alcohol/drug abuse or in treatment with disulfiram (antabus) at time of inclusion * Uncontrolled medical issues including but not limited to cardiovascular pulmonary, rheumatologic, hematologic, oncologic, infectious, gastrointestinal, or psychiatric disease; diabetes or other endocrine disease; immunosuppression * Current treatment with medication which significantly affect appetite or energy balance (e.g., GLP-1 receptor agonists) * Bariatric surgery * Unable to understand the informed consent and the study procedures * Concomitant participation in intervention studies * Participant's withdrawal of the informed consent * Other safety concerns - judged by the investigator
Where this trial is running
Herlev, Denmark
- Steno Diabetes Center Copenhagen — Herlev, Denmark, Denmark (Recruiting)
Study contacts
- Principal investigator: Jonas S Salling Quist, MSc, PhD — Steno Diabetes Center Copenhagen
- Study coordinator: Jonas S. Quist, MSc, PhD
- Email: jonas.salling.quist@regionh.dk
- Phone: +45 26176064
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.