Exploring how dietary potassium affects blood vessels in people with high sodium intake
Official title: Mechanisms Underlying the Protective Vascular Effects of Dietary Potassium in Humans
Run by University of Delaware · NCT04101188 · Data updated 2026-11-12
This study is testing if eating more potassium can help protect blood vessels in people who eat a lot of salt.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years to 45 Years |
| Sex | All |
| Enrollment | 90 (estimated) |
| Sponsor | University of Delaware Academic / other |
| Locations | 1 site (Newark, Delaware) |
| Status | Recruiting |
| Started | January 16, 2020 |
| Main results expected | July 31, 2026 |
| Study ends | July 31, 2026 |
| Registry record updated | March 4, 2026 |
| Trial ID | NCT04101188 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates for this study are healthy adults with normal blood pressure and no history of cardiovascular or metabolic diseases.
✕Probably not a fit
Patients with hypertension, heart disease, diabetes, kidney disease, obesity, or those on special diets may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This investigation focuses on understanding the effects of dietary potassium on vascular health in individuals consuming a high sodium diet. It aims to evaluate how potassium may mitigate sodium-induced vascular dysfunction, particularly in salt-resistant adults. The study will assess various dietary interventions, including moderate and high potassium diets alongside differing sodium levels, to determine their impact on endothelial function and oxidative stress. By examining these relationships, the research seeks to clarify the role of potassium in promoting vascular health amidst prevalent high sodium consumption.
Why it matters
Potential benefit: If successful, this study could provide insights into dietary strategies that improve vascular health and reduce cardiovascular disease risk.
How similar studies have gone: While the role of potassium in blood pressure management is well-established, the specific focus on its vascular effects in the context of high sodium intake is less explored, making this a novel investigation.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * healthy * normal blood pressure * normal resting ECG Exclusion Criteria: * hypertension * history of heart disease * diabetes * kidney disease * obese (BMI ≥30) * significant weight changes in the last 6 months * use of tobacco products * pregnant * on a special diet (gluten free; vegan) * take any medications for the above conditions * endurance trained athletes
Where it's running
-
University of Delaware
Newark, Delaware, United States Recruiting
Study contacts
- Principal investigator: Shannon L Lennon, PhD — University of Delaware
- Study coordinator: Shannon L Lennon, PhD
- Email: slennon@udel.edu
- Phone: (302)831-2798
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.