Exploring how cognitive reserve affects non-drug treatments for cognitive impairment
Implication of Cognitive Reserve in Non-pharmacological Intervention Outcomes
This study is testing how a brain stimulation treatment can help improve thinking skills in people with mild cognitive impairment and dementia, and whether having a strong cognitive reserve makes a difference in the results.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 55 (estimated) |
| Ages | 60 Years to 75 Years |
| Sex | All |
| Sponsor | Masaryk University Academic / other |
| Locations | 1 site (Brno) |
| Trial ID | NCT06563453 on ClinicalTrials.gov |
What this trial studies
This study investigates the role of cognitive reserve (CR) in the effectiveness of transcranial alternating current stimulation (tACS) for enhancing cognitive function in individuals with mild cognitive impairment and dementia with Lewy bodies. It employs advanced imaging techniques, including neuromelanin-sensitive MRI and resting-state functional MRI, to assess brain activity and connectivity. The goal is to identify which biomarkers of cognitive reserve best predict the cognitive benefits of tACS and how CR influences the brain's compensatory mechanisms during cognitive tasks. By combining dynamic and static measures of CR, the study aims to provide insights into personalized treatment approaches for cognitive decline.
Who should consider this trial
Good fit: Ideal candidates for this study are individuals with intact cognitive performance who have been diagnosed with mild cognitive impairment with Lewy bodies.
Not a fit: Patients with advanced dementia or significant psychiatric disorders may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to more effective non-pharmacological interventions for patients with cognitive impairment, enhancing their cognitive function and quality of life.
How similar studies have performed: While the approach of using cognitive reserve as a predictor in tACS interventions is relatively novel, similar studies have shown promise in enhancing cognitive function through non-pharmacological methods.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: 1. Intact cognitive performance as assessed by cognitive evaluation. 2. Subjects with possible or probable mild cognitive impairment with Lewy bodies (MCI-LB). Exclusion Criteria: Presence of dementia as assessed by a cognitive test battery and evaluation of daily activities. Any major psychiatric disorder. History of neurological disease affecting the central nervous system (e.g., tumor, epilepsy, stroke, etc.). Severe or repeated head injury. Non-compensated internal or oncological disease. MRI-incompatible metal in the body (e.g., pacemaker). Left-handedness.
Where this trial is running
Brno
- CEITEC Masaryk University — Brno, Czechia (Recruiting)
Study contacts
- Principal investigator: Ilona Eliášová, Ph.D. — Masaryk University
- Study coordinator: Kristina Mitterova, Ph.D.
- Email: kristina.mitterova@ceitec.muni.cz
- Phone: 735512163
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.