Exploring how achalasia affects outcomes after a specific esophageal surgery
Study on the Relationship Between Different Pathological Features of Achalasia and Prognosis of Per-oral Endoscopic Myotomy
This study looks at how different types of achalasia affect recovery after a specific esophageal surgery to help doctors better understand and treat this condition.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 50 (estimated) |
| Ages | 18 Years to 80 Years |
| Sex | All |
| Sponsor | Beijing Friendship Hospital Academic / other |
| Locations | 1 site (Beijing, Beijing) |
| Trial ID | NCT05113173 on ClinicalTrials.gov |
What this trial studies
This observational study investigates the relationship between the pathological features of esophageal achalasia and the prognosis following per-oral endoscopic myotomy (POEM). Participants with achalasia are categorized into three subtypes based on high-resolution manometry, and their esophageal muscular layers are analyzed for pathological characteristics. The study aims to understand how these features influence treatment outcomes, particularly focusing on the degeneration of nerve plexus and the presence of inflammatory cells. By correlating these findings with clinical outcomes, the research seeks to enhance the understanding of achalasia and improve patient management.
Who should consider this trial
Good fit: Ideal candidates for this study are adults aged 18 to 80 who have been diagnosed with achalasia and are eligible for POEM treatment.
Not a fit: Patients who have previously undergone treatment for achalasia or have other significant esophageal conditions may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved treatment strategies for patients with achalasia, enhancing surgical outcomes.
How similar studies have performed: Previous studies have indicated varying success in understanding the relationship between achalasia pathology and treatment outcomes, but this specific approach appears to be novel.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Participants with achalasia * Age: 18 to 80 years * Accept for the treatment of POEM * Sign the informed consent Exclusion Criteria: * Participants under 18 years old * Previously received treatment of achalasia, Barrett's esophagus, esophageal stricture, liver cirrhosis, and/or esophageal varices, tumors, allergic diseases and hiatal hernia. * Use non-steroidal anti-inflammatory drugs, corticosteroids and other immunosuppressive agents.
Where this trial is running
Beijing, Beijing
- Beijing Friendship Hospital — Beijing, Beijing, China (Recruiting)
Study contacts
- Principal investigator: Fandong Meng — Beijing Friendship Hospital
- Study coordinator: Fandong Meng
- Email: mfdzhaotianyu@163.com
- Phone: +8613681061594
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.