Exploring gut microbiota's role in lung complications after surgery in elderly patients

Gut Microbiota and Pulmonary Complications After Non Cardiac Elective Surgery in Elderly Patients

This study looks at how the bacteria in the gut and throat might affect lung problems after surgery in older patients.

Quick facts

• Study type: Observational
• Enrollment: 100 (estimated)
• Ages: 65 Years and up
• Sex: All
• Sponsor: Peking Union Medical College Hospital (Academic / other)
• Locations: 1 site (Beijing, Beijing Municipality)
• Trial ID: NCT06513416 on ClinicalTrials.gov

What this trial studies

This observational study investigates the relationship between the composition of gut and oropharyngeal microbiota and the occurrence of postoperative pulmonary complications in elderly patients undergoing elective upper abdominal surgery. It utilizes both retrospective and prospective cohort methods, collecting preoperative microbiota samples from participants aged 65 and older. The study aims to identify potential correlations that could inform postoperative care and improve outcomes for this vulnerable population.

Who should consider this trial

Good fit: Ideal candidates are elderly patients aged 65 and older who are scheduled for elective upper abdominal surgery.

Not a fit: Patients undergoing emergency surgery or those with recent pulmonary infections may not benefit from this study.

Why it matters

Potential benefit: If successful, this study could lead to improved strategies for preventing pulmonary complications in elderly surgical patients.

How similar studies have performed: While the specific approach of this study is novel, related research has shown that microbiota composition can influence postoperative outcomes.

Eligibility criteria

Inclusion Criteria:

1. Age: ≥ 65 years old;
2. Surgery: Upper abdominal surgery (expected duration ≥ 2 hours);
3. Anesthesia methods: general anesthesia, tracheal intubation;
4. ASA classification: I-IV levels;
5. Postoperative Pulmonary Complications Risk Score (ARISCAT): Medium to High Risk
6. Patients or their families are able to understand the research protocol and are willing to participate in this study, providing written informed consent

Exclusion Criteria:

1. Emergency surgery;
2. This is the second surgery within the past month;
3. Preoperative presence of pulmonary infection or other serious pulmonary complications
4. Patients who have used antibiotics, probiotics, and acid suppressants within one month before surgery

Where this trial is running

Beijing, Beijing Municipality

• Department of Anesthesiology, Peking Union Medical College Hospital — Beijing, Beijing Municipality, China (Recruiting)

Study contacts

• Study coordinator: Qianmei Zhu

Conditions Gut Microbiota; Postoperative Pulmonary Complications