Exploring gut metabolites and heart function in heart attack patients

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study investigates the relationship between intestinal microbial metabolites, specifically bile acids and short chain fatty acids, and cardiac function in patients who have experienced an acute myocardial infarction (AMI). By analyzing these metabolites, the study aims to understand their role in the pathophysiology of cardiovascular diseases and their potential as intervention targets. The research will involve patients aged 18-85 who have undergone coronary angiography and consented to participate. The findings could provide insights into how gut health impacts heart health, particularly in the context of AMI.

Why it matters

Who can join: the full rules

Inclusion Criteria:

The patient, aged 18-85 years, had undergone coronary angiography and agreed to be enrolled and signed the informed consent.

AMI : according to ST segment elevation myocardial infarction diagnostic criteria.

UAP:

1. typical chest pain symptoms;
2. negative in markers of myocardial injury;
3. The stenosis of main coronary artery or its main branches is more than 50%

Control:

1. atypical chest pain symptoms
2. negative in markers of myocardial injury;
3. The stenosis of main coronary artery and its main branches is less than 50%

Exclusion Criteria:

1. Acute infection or application of antibiotics in the past 3 months;
2. Chronic heart failure;
3. History of inflammatory or absorptive bowel disease and bowel resection;
4. Acute, chronic liver disease or other reasons lead to abnormal liver function (transaminase is more than 5 times of normal value);
5. Renal insufficiency (serum creatinine \> 220μml/L or creatinine clearance rate \< 30 ml/min);
6. Malignant tumor;
7. Autoimmune diseases;
8. Uninformed patients

Where it's running

• Peking University Third Hospital
  Beijing, Beijing, China Recruiting

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.