Exploring genomic testing for cancer of unknown primary

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study focuses on patients diagnosed with Cancer of Unknown Primary (CUP), a condition where the origin of cancer is not identified. The study aims to enhance understanding of the molecular characteristics of CUP through genomic testing, including the use of gene panel arrays and blood sample collection for liquid biopsies. By analyzing these samples, researchers hope to identify potential biomarkers that could lead to novel therapeutic strategies. The study addresses the challenges of limited treatment options and aims to improve patient outcomes in this difficult-to-treat cancer type.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1. Aged 16 years or over
2. Written informed consent according to ICH/GCP and national regulations
3. ECOG Performance status 0-2
4. Confirmed diagnosis of CUP as per the ESMO guidelines. Patients must have;

   1. The local pathology reports confirming compatibility with CUP diagnosis and the associated slides used for the diagnosis
   2. Discussion at a local CUP MDT confirming diagnosis
5. Availability of archival tumour histological report
6. Willingness to provide blood samples on up to two occasions during the study

Exclusion Criteria:

1. Patient with an immunohistochemistry profile that provides a definitive clinical indication of a primary cancer with a specific treatment
2. Known HIV, Hepatitis B, C positive, due to the difficulties in handling high-risk specimens
3. Patients who are unable to provide fully informed written consent
4. Presence of any medical, psychological, familial or sociological condition that, in the investigator's opinion, will hamper compliance with the study protocol and follow-up schedule
5. Bleeding diathesis (patients' on anticoagulation are permitted to enter the trial if anticoagulation can be safely managed to enable blood sampling)
6. Conditions in which blood sampling may increase risk of complications for the patients and/or investigator

Where it's running

• The Christie NHS Foundation Trust
  Manchester, Greater Manchester, United Kingdom Recruiting
• The Clatterbridge Cancer Centre NHS Foundation Trust
  Liverpool, Merseyside, United Kingdom Recruiting
• Blackpool Teaching Hospitals NHS Foundation Trust
  Blackpool, United Kingdom Recruiting
• Northern Care Alliance NHS Foundation Trust
  Manchester, United Kingdom Recruiting
• University Hospitals of Morecambe Bay NHS Trust
  Morecambe, United Kingdom Recruiting
• Lancashire Teaching Hospitals NHS Foundation Trust
  Preston, United Kingdom Recruiting

Study contacts

• Principal investigator: Natalie Cook — The University of Manchester
• Study coordinator: EGG CUP Study Team
• Email: the-christie.egg-cup@nhs.net
• Phone: +44 161 918 7672

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

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• Combined Proton Therapy and Liver Transplant for Hilar Cholangiocarcinoma

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• Proton beam therapy for parotid cancer after surgery

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.