Exploring genetic factors in malignant pleural mesothelioma

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study investigates the genetic susceptibility of individuals to malignant pleural mesothelioma (MPM), particularly focusing on germline variations and their clinical implications. The study aims to understand how asbestos exposure interacts with genetic predispositions to influence the development of MPM. By analyzing patients diagnosed with MPM and former asbestos-exposed healthy subjects, the research seeks to uncover potential genetic markers that could inform future therapeutic strategies. The study is set in the Pavia province, an area with ongoing asbestos exposure and a rising incidence of MPM.

Why it matters

Who can join: the full rules

Inclusion Criteria Cohort A:

* Patient with a documented diagnosis of MPM (any disease stage and independently from chemo line treatment)
* Age ≥ 18 years (there is no upper age limit).
* Patient who gives their informed consent to participate in the study

Exclusion Criteria Cohort A:

* No exclusion criteria

Inclusion Criteria Cohort B:

* Former asbestos exposed healthy subjects
* Age ≥ 18 years (there is no upper age limit).
* Subject who gives their informed consent to participate in the study

Exclusion Criteria Cohort B:

* No exclusion criteria

Where it's running

• Fondazione IRCCS Policlinico San Matteo
  Pavia, Pavia, Italy Recruiting
• IRCCS Istituti Clinici Maugeri, Medicina del Lavoro
  Pavia, Pavia, Italy Recruiting

Study contacts

• Study coordinator: Giulia Maria Stella, MD
• Email: g.stella@smatteo.pv.it
• Phone: +390382503369

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.