Exploring genetic factors in cerebral palsy
Genetic Predisposition in Cerebral Palsy
This study is trying to find out if certain genes might play a role in causing cerebral palsy in children aged 2 to 15 years.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 250 (estimated) |
| Ages | 2 Years to 15 Years |
| Sex | All |
| Sponsor | Hospices Civils de Lyon Academic / other |
| Locations | 2 sites (Bron and 1 other locations) |
| Trial ID | NCT05317234 on ClinicalTrials.gov |
What this trial studies
This study investigates the genetic predisposition to cerebral palsy (CP), a neurodevelopmental disorder affecting movement and posture. It aims to identify potential genetic or epigenetic factors that may contribute to CP, beyond the traditionally recognized causes related to pregnancy and delivery complications. The approach involves whole-exome sequencing to analyze the genetic makeup of children diagnosed with CP, aged between 2 and 15 years. The study seeks to enhance understanding of the underlying mechanisms of CP and potentially identify genetic variants associated with the condition.
Who should consider this trial
Good fit: Ideal candidates include children aged 2 to 15 years with a clinical diagnosis of cerebral palsy and both parents available for genetic study.
Not a fit: Patients with identified genetic syndromes or specific perinatal stroke etiologies may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved diagnosis and targeted interventions for children with cerebral palsy based on their genetic profiles.
How similar studies have performed: Other studies have suggested genetic factors in cerebral palsy, indicating a potential for success in this novel approach.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Child between 2 and 15 years old with a clinical diagnostic of cerebral paralysis with unilateral or bilateral somatic involvement * Child born from 34 SA * Agreement of the legal representatives for the genetic study * Both parents available for a parental genetic study (if detection of class 3 variant) * Affiliation to the social security system Exclusion Criteria: * Genetic syndrome identified or malformative or infectious etiologies identified * Neonatal encephalopathy criteria in a clear obstetrical etiological context responsible for major perinatal anoxia with Sarnat 2 or 3 * Unilateral motor disorders in perinatal stroke of identified etiology (coagulation anomaly)
Where this trial is running
Bron and 1 other locations
- Service de Médecine Physique et Réadaptation Pédiatrique - Hôpital Femme-Mère-Enfant — Bron, France (Recruiting)
- Service de médecine physique et réadaptative pédiatrique, Pôle pédiatrie-Génétique - Hôpital Couple-Enfant — Grenoble, France (Not_yet_recruiting)
Study contacts
- Study coordinator: Cyril Huissoud, Pr
- Email: Cyril.huissoud@chu-lyon.fr
- Phone: +33427856565
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.