Exploring fertility preservation and health outcomes in female cancer patients
Official title: Fertility Preservation and Pregnancy and Offspring Health Outcomes in Female Cancer Patients: A Multicenter, Prospective, Cohort Study
Run by The First Affiliated Hospital with Nanjing Medical University · NCT06360471 · Data updated 2026-11-12
This study is testing if women with cancer who take steps to save their ability to have children before treatment have better chances of having healthy babies compared to those who don’t and to women without cancer.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 20 Years to 40 Years |
| Sex | Women only |
| Enrollment | 2800 (estimated) |
| Sponsor | The First Affiliated Hospital with Nanjing Medical University Academic / other |
| Locations | 1 site (Nanjing, Jiangsu) |
| Status | Recruiting |
| Started | October 1, 2023 |
| Main results expected | October 1, 2027 |
| Study ends | October 1, 2032 |
| Registry record updated | April 16, 2024 |
| Trial ID | NCT06360471 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates for this study are women aged 20-40 diagnosed with malignant cancers who desire to preserve their fertility.
✕Probably not a fit
Patients with congenital or acquired uterine abnormalities, severe intrauterine adhesions, or those with contraindications to assisted reproductive technology may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This observational study aims to investigate the differences in cumulative live birth rates and maternal and child health outcomes between female cancer patients who undergo fertility preservation before anti-tumor treatment and those who do not, as well as non-cancer patients undergoing assisted reproductive technology or natural pregnancy. The study will enroll 2800 women diagnosed with various malignant cancers who wish to preserve their fertility. Participants will be observed over the long term to assess the impact of fertility preservation on reproductive outcomes and offspring health. Statistical analyses will be conducted to evaluate the data collected.
Why it matters
Potential benefit: If successful, this study could provide valuable insights into the benefits of fertility preservation for female cancer patients, potentially improving their reproductive outcomes and offspring health.
How similar studies have gone: Other studies have shown promising results regarding fertility preservation in cancer patients, indicating that this approach is supported by existing evidence.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: 1. Tumor confirmed (main focus: breast cancer, hematological disease/lymphoma, gynecological tumor (ovarian cancer), boundary tumors, nasopharyngeal cancer, colorectal cancer, and other tumors that require anti-tumor treatment; 2. Having a desire for future fertility(including women who have already given birth); 3. Age: 20-40 years old (patients planning to freeze their eggs are ≤35 years old, and those planning to freeze their embryos are ≤40 years old); 4. Consent. Exclusion Criteria: 1. Patients with congenital or acquired uterine abnormalities, severe intrauterine adhesions, and other diseases that have a clear impact on pregnancy; 2. Those with assisted reproductive technology and pregnancy contraindications; 3. Tumors that are not suitable for pregnancy after multidisciplinary discussions on tumor fertility; 4. Clinical diagnosis of POI (premature ovarian insufficiency).
Where it's running
-
Clinical Center of Reproductive Medicine of First Affiliated Hospital with Nanjing Medical University
Nanjing, Jiangsu, China Recruiting
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.