Exploring different levels of ventilator support for patients with acute respiratory failure
Neural Pressure Support, a Randomized Crossover Trial
This study is testing different levels of breathing support for patients on a ventilator to see which helps them breathe better and feel more comfortable.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 22 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | Karolinska Institutet Academic / other |
| Locations | 1 site (Solna) |
| Trial ID | NCT05670093 on ClinicalTrials.gov |
What this trial studies
This interventional study focuses on patients who have been intubated and on mechanical ventilation for over 24 hours. It employs a randomized crossover design to compare three levels of ventilatory support: baseline, 50%, and 150% of baseline, using both Pressure Support and Neural Pressure Support modes. The study aims to assess patient-ventilator synchrony and respiratory muscle unloading by recording ventilator curves and obtaining blood gas measurements at the end of each 20-minute intervention phase.
Who should consider this trial
Good fit: Ideal candidates are patients who have been intubated for more than 24 hours and are in the weaning phase from mechanical ventilation.
Not a fit: Patients with bleeding disorders, unstable circulation, severe lung disease, fever, or those who are pregnant may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could improve ventilator management strategies for patients with acute respiratory failure, leading to better patient outcomes.
How similar studies have performed: While the specific approach of Neural Pressure Support is novel, similar studies exploring ventilator support strategies have shown promise in improving patient outcomes.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: -Patients intubated for more than 24 hours in the weaning phase from the ventilator. Exclusion Criteria: * bleeding disorders (PK INR\>1,5 or APTT\>50s or platelet count \<50000/µL) * unstable circulation (requiring high vasopressor dose, for example Noradrenalin \>0,2µg/kg/min) * severe lung disease (PFI ≤ 13,3 kPa) * fever\> 38,5°C * pregnancy.
Where this trial is running
Solna
- Karolinska University Hospital — Solna, Sweden (Recruiting)
Study contacts
- Principal investigator: Francesca Campoccia Jalde — Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden.
- Study coordinator: Campoccia Jalde
- Email: francesca.campoccia-jalde@regionstockholm.se
- Phone: +46703947741
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.