Exploring coronary microvascular dysfunction in angina patients without significant artery blockages
Coronary Microvascular Dysfunction in Angina Patients With Non-obstructive Coronary Artery Disease
China-Japan Friendship Hospital · NCT06503640
This study is trying to understand how small blood vessel problems in the heart affect people with chest pain who don’t have major artery blockages.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 100 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | China-Japan Friendship Hospital (other) |
| Locations | 1 site (Beijing, Beijing Municipality) |
| Trial ID | NCT06503640 on ClinicalTrials.gov |
What this trial studies
This observational study aims to investigate the incidence and impact of coronary microvascular dysfunction in patients experiencing stable anginal symptoms who are indicated for invasive coronary angiography but do not have significant epicardial coronary artery disease. The study will assess patients with a fractional flow reserve greater than 0.80, focusing on understanding how microvascular dysfunction affects their prognosis. By analyzing these patients, the study seeks to provide insights into a condition that is often overlooked in traditional assessments of coronary artery health.
Who should consider this trial
Good fit: Ideal candidates are patients with stable anginal symptoms and no significant epicardial coronary artery disease.
Not a fit: Patients with acute myocardial infarction, significant valvular heart disease, or advanced chronic kidney disease may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to better understanding and management of angina in patients with non-obstructive coronary artery disease.
How similar studies have performed: While this approach is not widely tested, similar studies have begun to explore coronary microvascular dysfunction, indicating potential for valuable insights.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * presence of stable anginal symptoms, a clinical indication for invasive coronary angiography, and no hemodynamically significant epicardial coronary artery disease, defined as fractional flow reserve (FFR) \>0.80 Exclusion Criteria: 1. acute myocardial infarction 2. significant valvular heart disease 3. advanced chronic kidney disease 4. patients with significant epicardial coronary artery stenosis (\>70% in major vessels by diagnostic coronary angiography) needing percutaneous coronary intervention 5. patients unable to provide written informed consent
Where this trial is running
Beijing, Beijing Municipality
- China-Japan Friendship Hospital — Beijing, Beijing Municipality, China (RECRUITING)
Study contacts
- Study coordinator: Zhaoxue Sheng, Doctor
- Email: shengzhaoxue@163.com
- Phone: +86-15600268925
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions: Angina Patients With Non-obstructive Coronary Artery Disease, Coronary Microvascular Dysfunction, Index of Microvascular Resistance