Exploring cognitive functions in bipolar and major depressive disorders
Social Cognition, Memory, and Executive Functions in Bipolar Disorder and Major Depressive Disorder
NA · CHU de Reims · NCT06740331
This study is trying to see how thinking skills are affected in people with bipolar disorder and major depression, and how these issues impact their daily lives and relationships.
Quick facts
| Phase | NA |
|---|---|
| Study type | Interventional |
| Enrollment | 180 (estimated) |
| Ages | 18 Years to 65 Years |
| Sex | All |
| Sponsor | CHU de Reims (other) |
| Locations | 1 site (Reims) |
| Trial ID | NCT06740331 on ClinicalTrials.gov |
What this trial studies
This study investigates the cognitive impairments associated with bipolar disorder (BD) and major depressive disorder (MDD), focusing on social cognition, memory, and executive functions. It aims to understand how these cognitive deficits affect functional outcomes and quality of life in individuals with these disorders. By analyzing the relationship between social cognition and executive functions, the study seeks to identify distinctive markers that could improve diagnosis and treatment strategies. Participants will include individuals diagnosed with BD or MDD, as well as their first-degree relatives.
Who should consider this trial
Good fit: Ideal candidates are individuals aged 18 to 65 with a diagnosis of bipolar disorder or major depressive disorder who are native French speakers.
Not a fit: Patients with significant substance use disorders, major medical illnesses, or uncorrected sensory impairments may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved diagnostic accuracy and treatment strategies for patients with bipolar disorder and major depressive disorder.
How similar studies have performed: While cognitive impairments in these disorders have been studied, this specific approach to linking social cognition and executive functions is relatively novel.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion criteria: * Patients between 18 and 65 years old, men or women * Having a diagnosis of bipolar disorder or depressive disorder * No substantial change in treatment for 2 weeks preceding study enrollment * Being a native French speaker * Patients enrolled in the national healthcare insurance program * Consenting to participate to the study Exclusion criteria: * The presence of any alcohol use disorder or any other substance use disorder in the last six months, except for tobacco dependence * A significant general medical illness, including neurological disorders or head trauma * A sensorial impairment uncorrected (visual and/or hearing) Group 3: First-degree relatives of bipolar patients Inclusion criteria: * Participants between 18 and 65 years old, men or women * Participants having at least one first-degree relative presenting an bipolar disorder (parents, children, siblings) * Being a native French speaker * Patients enrolled in the national healthcare insurance program * Consenting to participate to the study Exclusion criteria: * A diagnosis of schizophrenia or of bipolar disorder or of depressive disorder according to DSM-5 criteria * The presence of any alcohol use disorder or any other substance use disorder in the last six months, except for tobacco dependence * A significant general medical illness, including neurological disorders or head trauma * A sensorial impairment uncorrected (visual and/or hearing) Group 4, 5, 6: Healthy control participants Inclusion criteria: * Participants between 18 and 65 years old, men or women * Being a native French speaker * Patients enrolled in the national healthcare insurance program * Consenting to participate to the study Exclusion criteria: * A diagnosis of schizophrenia or of bipolar disorder or of major depressive disorder according to DSM-5 criteria * The presence of any alcohol use disorder or any other substance use disorder in the last six months, except for tobacco dependence * Participants having one first-degree relative presenting an bipolar disorder or depressive disorder or schizophrenia according to DSM-5 criteria * A significant general medical illness, including neurological disorders or head trauma * A sensorial impairment uncorrected (visual and/or hearing)
Where this trial is running
Reims
- Chu Reims — Reims, France (RECRUITING)
Study contacts
- Study coordinator: Arthur KALADJIAN
- Email: kaladjiana@epsm-marne.fr
- Phone: 03 26 78 70 45
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions: Bipolar Disorder and Major Depressive Disorder, Bipolar disorder, major depressive disorder, high-risk individuals, social cognition, executive functions, memory functions