Exploring cognitive functions in bipolar and major depressive disorders

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study investigates the cognitive impairments associated with bipolar disorder (BD) and major depressive disorder (MDD), focusing on social cognition, memory, and executive functions. It aims to understand how these cognitive deficits affect functional outcomes and quality of life in individuals with these disorders. By analyzing the relationship between social cognition and executive functions, the study seeks to identify distinctive markers that could improve diagnosis and treatment strategies. Participants will include individuals diagnosed with BD or MDD, as well as their first-degree relatives.

Why it matters

Who can join: the full rules

Inclusion criteria:

* Patients between 18 and 65 years old, men or women
* Having a diagnosis of bipolar disorder or depressive disorder
* No substantial change in treatment for 2 weeks preceding study enrollment
* Being a native French speaker
* Patients enrolled in the national healthcare insurance program
* Consenting to participate to the study

Exclusion criteria:

* The presence of any alcohol use disorder or any other substance use disorder in the last six months, except for tobacco dependence
* A significant general medical illness, including neurological disorders or head trauma
* A sensorial impairment uncorrected (visual and/or hearing)

Group 3: First-degree relatives of bipolar patients

Inclusion criteria:

* Participants between 18 and 65 years old, men or women
* Participants having at least one first-degree relative presenting an bipolar disorder (parents, children, siblings)
* Being a native French speaker
* Patients enrolled in the national healthcare insurance program
* Consenting to participate to the study

Exclusion criteria:

* A diagnosis of schizophrenia or of bipolar disorder or of depressive disorder according to DSM-5 criteria
* The presence of any alcohol use disorder or any other substance use disorder in the last six months, except for tobacco dependence
* A significant general medical illness, including neurological disorders or head trauma
* A sensorial impairment uncorrected (visual and/or hearing)

Group 4, 5, 6: Healthy control participants

Inclusion criteria:

* Participants between 18 and 65 years old, men or women
* Being a native French speaker
* Patients enrolled in the national healthcare insurance program
* Consenting to participate to the study

Exclusion criteria:

* A diagnosis of schizophrenia or of bipolar disorder or of major depressive disorder according to DSM-5 criteria
* The presence of any alcohol use disorder or any other substance use disorder in the last six months, except for tobacco dependence
* Participants having one first-degree relative presenting an bipolar disorder or depressive disorder or schizophrenia according to DSM-5 criteria
* A significant general medical illness, including neurological disorders or head trauma
* A sensorial impairment uncorrected (visual and/or hearing)

Where it's running

• Chu Reims
  Reims, France Recruiting

Study contacts

• Study coordinator: Arthur KALADJIAN
• Email: kaladjiana@epsm-marne.fr
• Phone: 03 26 78 70 45

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Does the order of endurance and strength training in COPD rehab matter for muscle strength?

  This study tests whether doing strength training before endurance training during pulmonary rehab improves muscle strength in adults with COPD.

  Recruiting CHU de Reims · Reims · NCT07655011

• Right ventricular–arterial coupling during fluid loading in ICU patients

  This study tests how the right ventricle handles fluid changes in critically ill adults to see how it affects blood flow and congestion.

  Recruiting CHU de Reims · Reims · NCT07537621

• Social cognition in severe alcohol use disorder

  This study tests how social-cognition abilities relate to brain structure in adults with severe alcohol use disorder who are abstinent and receiving care.

  Recruiting CHU de Reims · Reims, Reims · NCT07464613

• PALMIRE cohort: phenotyping inflammatory lung diseases to enable personalized care

  This project will collect clinical, imaging, and biological data from adults with asthma, COPD, bronchiectasis, cystic fibrosis, primary ciliary dyskinesia, or interstitial lung disease to try to identify disease subtypes and markers that could guide more personalized care.

  Recruiting CHU de Reims · Reims · NCT07274631

• Antiphospholipid syndrome in people 65 and older who had an ischemic stroke

  This study will test whether routine blood testing for antiphospholipid antibodies in people aged 65 and over hospitalized with ischemic stroke or TIA can identify previously unrecognized antiphospholipid syndrome.

  Recruiting CHU de Reims · Reims · NCT07163338

• French translation and validation of the mPCOSQ quality-of-life questionnaire for women with PCOS.

  This project tests a French version of the mPCOSQ to see if it reliably measures health-related quality of life in French-speaking women with PCOS aged 18–45.

  Recruiting CHU de Reims · Reims · NCT07016035

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.