Exploring causes and treatments for postural puncture headache

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study aims to investigate the pathophysiology of post-dural puncture headache (PDPH) using advanced MRI techniques. By examining cerebral blood flow, cerebrospinal fluid dynamics, and the effects of epidural blood patches, the study seeks to enhance understanding of this common complication following lumbar punctures. The research focuses on how dural puncture alters central nervous system dynamics and aims to provide insights that could lead to improved treatment options for affected patients.

Why it matters

Who can join: the full rules

Inclusion Criteria:

Postural puncture headache Age 20-40

Exclusion Criteria:

* Other central neurological disorders except the actual
* Acute medical condition
* Pregnancy
* Pacemaker, or other medical implants that are not MRI-compatible
* Invasive procedures on the central nervous system or surgery on the spine or brain in the last 12 months.

Where it's running

• Umeå University Hospital
  Umeå, Västerbotten County, Sweden Recruiting

Study contacts

• Principal investigator: Laleh Zarrinkoob, MD, PhD — Umeå University
• Study coordinator: Erik Burman, MD
• Email: erik.burman@regionvasterbotten.se
• Phone: 907864594

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Epidural hydroxyethyl starch to prevent post-dural puncture headache in parturients

  This study tests whether filling the epidural space with hydroxyethyl starch can help prevent post-dural puncture headaches in women who had an accidental dural puncture during epidural anesthesia for labor or cesarean delivery.

  Recruiting Peking University First Hospital · Beijing, Beijing Municipality and 3 other locations · NCT07914790

• Predicting Post-Dural Puncture Headache After Spinal Anesthesia in Cesarean Deliveries

  This study tests whether changes in optic nerve sheath diameter after spinal anesthesia can predict who will develop a post-dural puncture headache in pregnant women having an elective cesarean.

  Recruiting Ordu University · Ordu, Altinordu · NCT07729449

• Treating post-dural puncture headache with theophylline, sumatriptan, or gabapentin

  This trial will try theophylline, sumatriptan, and gabapentin to see which best relieves moderate-to-severe post-dural puncture headache in adults aged 21–50.

  Recruiting Tanta University · Tanta, El-Gharbia · NCT07515456

• Sphenopalatine ganglion block versus epidural blood patch for post-dural puncture headache

  This test compares a sphenopalatine ganglion block and an epidural blood patch to see which relieves post-dural puncture headaches better in adults whose pain hasn't improved after 24 hours of usual treatment.

  Recruiting Phase 3 University Hospital, Clermont-Ferrand · Clermont-Ferrand · NCT07354464

• Nebulized neostigmine/atropine versus nebulized lidocaine for post-dural puncture headache after cesarean delivery

  This trial tests whether inhaled (nebulized) neostigmine with atropine relieves post-dural puncture headache better than inhaled lidocaine in women who develop headache after spinal anesthesia for elective cesarean delivery.

  Recruiting Early Phase 1 Minia University · Minya · NCT06824025

• Impact of altitude on headaches after cesarean delivery

  This study is testing how living at different altitudes affects the headaches that women experience after having a cesarean delivery with spinal anesthesia.

  Recruiting at 2 sites B.P. Koirala Institute of Health Sciences · Jumla, Karnali and 1 other locations · NCT05804448

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.