Exploring causes and treatments for postural puncture headache
Cerebral Hemodynamics and Cerebrospinal Fluid Dynamics in Postdural Puncture Headache An MRI Study for Exploring the Pathophysiological Mechanisms and Implication of Treatment
This study is trying to understand what causes post-dural puncture headaches and how treatments like epidural blood patches can help people who get them after a lumbar puncture.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 160 (estimated) |
| Ages | 20 Years to 40 Years |
| Sex | All |
| Sponsor | Umeå University Academic / other |
| Locations | 1 site (Umeå, Västerbotten County) |
| Trial ID | NCT06253754 on ClinicalTrials.gov |
What this trial studies
This observational study aims to investigate the pathophysiology of post-dural puncture headache (PDPH) using advanced MRI techniques. By examining cerebral blood flow, cerebrospinal fluid dynamics, and the effects of epidural blood patches, the study seeks to enhance understanding of this common complication following lumbar punctures. The research focuses on how dural puncture alters central nervous system dynamics and aims to provide insights that could lead to improved treatment options for affected patients.
Who should consider this trial
Good fit: Ideal candidates for this study are individuals aged 20-40 who are experiencing postural puncture headaches.
Not a fit: Patients with other central neurological disorders, acute medical conditions, or those who are pregnant will not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to better treatment strategies for patients suffering from post-dural puncture headache.
How similar studies have performed: While there have been studies on PDPH, this approach using advanced MRI to explore its pathophysiology is relatively novel.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: Postural puncture headache Age 20-40 Exclusion Criteria: * Other central neurological disorders except the actual * Acute medical condition * Pregnancy * Pacemaker, or other medical implants that are not MRI-compatible * Invasive procedures on the central nervous system or surgery on the spine or brain in the last 12 months.
Where this trial is running
Umeå, Västerbotten County
- Umeå University Hospital — Umeå, Västerbotten County, Sweden (Recruiting)
Study contacts
- Principal investigator: Laleh Zarrinkoob, MD, PhD — Umeå University
- Study coordinator: Erik Burman, MD
- Email: erik.burman@regionvasterbotten.se
- Phone: 907864594
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.