Exploring brain temperature and pressure patterns in acute brain injury
Correlation Patterns of Brain Temperature-Pressure in Acute Brain Injury：a Multicenter Prospective Cohort Study, MERCURY
This study looks at how brain temperature and pressure change in adults with serious brain injuries to see if these patterns can help predict recovery after 30 days.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 150 (estimated) |
| Ages | 18 Years to 65 Years |
| Sex | All |
| Sponsor | Beijing Tiantan Hospital Academic / other |
| Locations | 1 site (Beijing, Beijing) |
| Trial ID | NCT06101537 on ClinicalTrials.gov |
What this trial studies
This observational study aims to investigate the relationship between brain temperature and intracranial pressure in patients with acute brain injuries, such as subarachnoid hemorrhage and cerebral hemorrhage. By continuously monitoring brain temperature alongside intracranial pressure, the study seeks to identify patterns that may predict neurological outcomes 30 days post-injury. The research will involve adult participants who have undergone intracranial pressure monitoring, allowing for a detailed analysis of how these two factors correlate and their implications for patient prognosis.
Who should consider this trial
Good fit: Ideal candidates for this study are adults aged 18 to 65 with acute brain injuries and a Glasgow Coma Scale score between 3 and 12.
Not a fit: Patients with a Glasgow Coma Scale score of 13 or higher, or those with certain contraindications such as intracranial infections or tumors, may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved monitoring and intervention strategies for patients with acute brain injuries, enhancing their recovery prospects.
How similar studies have performed: While the correlation between brain temperature and intracranial pressure is a relatively novel area of investigation, previous studies have indicated the importance of temperature monitoring in brain injury management.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: 1. Adults, male or female, 18 to 65 years of age; 2. Acute brain injury due to subarachnoid hemorrhage, cerebral hemorrhage, or craniocerebral trauma; 3. Glasgow Coma Scale (GCS) score of 3-12; 4. Have undergone intracranial pressure monitoring probe placement, which allows continuous recording of brain temperature and pressure data; 5. Signed informed consent. Exclusion Criteria: 1. GCS ≥13 points; 2. Patients with concomitant intracranial infections, cerebral ischemia, congenital malformations, autoimmune encephalitis, or craniocerebral tumors; 3. At the time of onset, there was a combination of systemic malignant tumor, acute stage of major systemic organ disease, or stage of functional decompensation; 4. Maternity; 5. Undergoing experimental drug or instrumental trials.
Where this trial is running
Beijing, Beijing
- Beijing Tiantan Hospital, Capital Medical University — Beijing, Beijing, China (Recruiting)
Study contacts
- Principal investigator: Guoyi Gao, MD — Beijing Tiantan Hospital
- Study coordinator: Liang Wu, MD
- Email: wuliang@bjtth.org
- Phone: 15001333582
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.