Exploring brain stimulation effects on cognitive impairment in Parkinson's disease
Effect and Mechanism of Deep Brain Stimulation and Transcranial Magnetic Stimulation on Parkinson's Disease With Cognitive Impairment
This study is testing how brain stimulation treatments can help improve thinking and memory problems in people with Parkinson's disease.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 200 (estimated) |
| Ages | N/A to 75 Years |
| Sex | All |
| Sponsor | Tianjin Huanhu Hospital Academic / other |
| Locations | 1 site (Tianjin, Tianjin Municipality) |
| Trial ID | NCT06090682 on ClinicalTrials.gov |
What this trial studies
This observational study aims to investigate the effects of deep brain stimulation (DBS) and transcranial magnetic stimulation (TMS) on cognitive impairment in patients with Parkinson's disease (PD). Utilizing advanced neuroimaging techniques, the study will analyze structural and functional brain network changes before and after treatment. By examining the relationship between neural regulation and cognitive symptoms, the research seeks to identify optimal stimulation sites and improve clinical outcomes for PD patients. The findings could provide insights into the mechanisms underlying cognitive decline in Parkinson's disease.
Who should consider this trial
Good fit: Ideal candidates for this study are individuals diagnosed with Parkinson's disease for over five years who exhibit cognitive impairment and are eligible for deep brain stimulation.
Not a fit: Patients with severe cognitive impairment, psychiatric disorders, or atypical parkinsonism may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved cognitive function in Parkinson's disease patients through targeted brain stimulation techniques.
How similar studies have performed: Previous studies have shown promising results with brain stimulation techniques in improving cognitive symptoms in Parkinson's disease, indicating potential for success in this approach.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: 1\. The clinical diagnosis of PD is consistent with the United Kingdom Parkinson's Disease Society Brain Bank criteria, with disease duration over 5 years, acute levodopa motor response ≥30%, and indication for STN-DBS. Exclusion Criteria: Exclusion criteria included patients with severe cognitive impairment, severe psychiatric disorders, acute levodopa motor response less than 30%, atypical parkinsonism, and contraindications to surgery.
Where this trial is running
Tianjin, Tianjin Municipality
- Tianjin Huanhu Hospital — Tianjin, Tianjin Municipality, China (Recruiting)
Study contacts
- Study coordinator: Zhao Guangrui, doctor
- Email: Guangrui-Zhao@hotmail.com
- Phone: +86 18956405513
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.