Exploring brain stimulation effects on cognitive impairment in Parkinson's disease

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study aims to investigate the effects of deep brain stimulation (DBS) and transcranial magnetic stimulation (TMS) on cognitive impairment in patients with Parkinson's disease (PD). Utilizing advanced neuroimaging techniques, the study will analyze structural and functional brain network changes before and after treatment. By examining the relationship between neural regulation and cognitive symptoms, the research seeks to identify optimal stimulation sites and improve clinical outcomes for PD patients. The findings could provide insights into the mechanisms underlying cognitive decline in Parkinson's disease.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1\. The clinical diagnosis of PD is consistent with the United Kingdom Parkinson's Disease Society Brain Bank criteria, with disease duration over 5 years, acute levodopa motor response ≥30%, and indication for STN-DBS.

Exclusion Criteria:

Exclusion criteria included patients with severe cognitive impairment, severe psychiatric disorders, acute levodopa motor response less than 30%, atypical parkinsonism, and contraindications to surgery.

Where it's running

• Tianjin Huanhu Hospital
  Tianjin, Tianjin Municipality, China Recruiting

Study contacts

• Study coordinator: Zhao Guangrui, doctor
• Email: Guangrui-Zhao@hotmail.com
• Phone: +86 18956405513

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.