Exploring brain health using non-invasive imaging techniques
Exploring Markers of Brain Health With EEG and TMS: A Pilot Study
This study is testing how brain responses to magnetic stimulation can help us learn more about brain health in people already involved in a related research project.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 63 (estimated) |
| Ages | 22 Years to 100 Years |
| Sex | All |
| Sponsor | The University of Texas at Dallas Academic / other |
| Locations | 1 site (Dallas, Texas) |
| Trial ID | NCT06731452 on ClinicalTrials.gov |
What this trial studies
This pilot study investigates neurophysiological markers of brain health by utilizing a combination of transcranial magnetic stimulation (TMS) and electroencephalography (EEG). Participants, who are already involved in a related study, will undergo two in-person sessions with the Delphi-MD device to assess brain responses to magnetic stimulation. The study aims to correlate these neurophysiological metrics with behavioral and fMRI data collected from the participants. This innovative approach seeks to enhance our understanding of brain health through non-invasive imaging.
Who should consider this trial
Good fit: Ideal candidates are individuals aged 22 and older who are active participants in The BrainHealth Project and meet specific safety criteria.
Not a fit: Patients with neurodegenerative diseases, significant brain injuries, or certain medical implants will not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved methods for assessing and promoting brain health.
How similar studies have performed: While this approach is innovative, similar studies using TMS and EEG have shown promise in understanding brain function.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Must be an active brain imaging participant in The BrainHealth Project (NCT04869111) * Minimum age of 22 * Fluent in English * Able to read \& hear information over a computer * Must pass an MRI safety screener to assess the presence of contraindicators for MRI compatibility (i.e., non-removable metal within/on the body, claustrophobia, pregnancy, non-correctable vision problems, head trauma, and CNS disease)or other standard requirements as determined by the Imaging Center. * Must pass a modified TMS Adult Safety Screen * Meet all criteria for study as determined by the study physician Exclusion Criteria: * A diagnosis of a neurodegenerative disease * A history of stroke, concussion, or brain injury that currently hinders them from functioning at their prior level * A diagnosis of autism spectrum disorder that currently hinders them from functioning independently. * Metallic brain implants or fragments (like a shunt, pacemaker, clips, coils, bullet fragments, cochlear implants) * Magnetically activated implants or electronically implanted devices * Medication pumps * Personal or family history of epilepsy, seizure(s), seizure disorder. * History of, or risk factors for syncope (fainting) * Report significant cognitive challenges * Report untreated health issues (like substance abuse, hypertension, hypo- or hyper-thyroidism) * Have claustrophobia
Where this trial is running
Dallas, Texas
- Center for BrainHealth at The University of Texas at Dallas — Dallas, Texas, United States (Recruiting)
Study contacts
- Principal investigator: Sandra Chapman, PhD — The University of Texas at Dallas
- Study coordinator: Erin Venza, MS
- Email: erin.venza@utdallas.edu
- Phone: 972-883-3208
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.